bcl-2 Homologous Antagonist-Killer Protein

"bcl-2 Homologous Antagonist-Killer Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A multi-domain mitochondrial membrane protein and member of the bcl-2 Protein family. Bak protein interacts with TUMOR SUPPRESSOR PROTEIN P53 and promotes APOPTOSIS.

Descriptor ID

D050998

MeSH Number(s)

D12.644.360.075.718.750

D12.776.476.075.718.425

Concept/Terms

bcl-2 Homologous Antagonist-Killer Protein

N-Bak Protein

Below are MeSH descriptors whose meaning is more general than "bcl-2 Homologous Antagonist-Killer Protein".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Apoptosis Regulatory Proteins [D12.644.360.075]
Proto-Oncogene Proteins c-bcl-2 [D12.644.360.075.718]
bcl-2 Homologous Antagonist-Killer Protein [D12.644.360.075.718.750]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Apoptosis Regulatory Proteins [D12.776.476.075]
Proto-Oncogene Proteins c-bcl-2 [D12.776.476.075.718]
bcl-2 Homologous Antagonist-Killer Protein [D12.776.476.075.718.425]

Below are MeSH descriptors whose meaning is related to "bcl-2 Homologous Antagonist-Killer Protein".

Below are MeSH descriptors whose meaning is more specific than "bcl-2 Homologous Antagonist-Killer Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "bcl-2 Homologous Antagonist-Killer Protein" by people in Harvard Catalyst Profiles by year, and whether "bcl-2 Homologous Antagonist-Killer Protein" was a major or minor topic of these publication.

Bar chart showing 50 publications over 19 distinct years, with a maximum of 7 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
2000	0	2	2
2001	0	1	1
2002	0	1	1
2003	0	1	1
2004	0	2	2
2005	0	4	4
2006	1	2	3
2008	0	2	2
2009	2	2	4
2010	1	2	3
2011	1	2	3
2012	1	1	2
2013	5	2	7
2015	3	0	3
2016	0	5	5
2017	2	1	3
2019	1	0	1
2023	0	2	2

Below are the most recent publications written about "bcl-2 Homologous Antagonist-Killer Protein" by people in Profiles.

Quantifying requirements for mitochondrial apoptosis in CAR T killing of cancer cells. Cell Death Dis. 2023 04 13; 14(4):267.

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Peptides from human BNIP5 and PXT1 and non-native binders of pro-apoptotic BAK can directly activate or inhibit BAK-mediated membrane permeabilization. Structure. 2023 03 02; 31(3):265-281.e7.

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Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK-Dependent Cell Death. Cancer Discov. 2022 03 01; 12(3):774-791.

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Downstream events initiated by expression of FSHD-associated DUX4: Studies of nucleocytoplasmic transport, ?H2AX accumulation, and Bax/Bak-dependence. Biol Open. 2022 02 15; 11(2).

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CD36 and ERK5 link dyslipidemia to apoptotic-like platelet procoagulant function. Curr Opin Hematol. 2019 09; 26(5):357-365.

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Reduced apoptosis in Chinese hamster ovary cells via optimized CRISPR interference. Biotechnol Bioeng. 2019 07; 116(7):1813-1819.

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Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK. Cell. 2018 05 17; 173(5):1217-1230.e17.

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Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria. Nat Commun. 2017 10 06; 8(1):803.

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MicroRNA-125a promotes resistance to BRAF inhibitors through suppression of the intrinsic apoptotic pathway. Pigment Cell Melanoma Res. 2017 05; 30(3):328-338.

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Variants in BAK1, SPRY4, and GAB2 are associated with pediatric germ cell tumors: A report from the children's oncology group. Genes Chromosomes Cancer. 2017 07; 56(7):548-558.

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