"Presenilin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN1 mutations cause early-onset ALZHEIMER DISEASE type 3 that may occur as early as 30 years of age in humans.
Below are MeSH descriptors whose meaning is more general than "Presenilin-1".
Below are MeSH descriptors whose meaning is more specific than "Presenilin-1".
This graph shows the total number of publications written about "Presenilin-1" by people in Harvard Catalyst Profiles by year, and whether "Presenilin-1" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1995 | 0 | 4 | 4 |
1996 | 0 | 13 | 13 |
1997 | 0 | 16 | 16 |
1998 | 0 | 19 | 19 |
1999 | 0 | 14 | 14 |
2000 | 0 | 19 | 19 |
2001 | 0 | 11 | 11 |
2002 | 0 | 10 | 10 |
2003 | 0 | 16 | 16 |
2004 | 0 | 14 | 14 |
2005 | 0 | 11 | 11 |
2006 | 1 | 3 | 4 |
2007 | 2 | 5 | 7 |
2008 | 3 | 4 | 7 |
2009 | 2 | 4 | 6 |
2010 | 9 | 7 | 16 |
2011 | 4 | 3 | 7 |
2012 | 8 | 8 | 16 |
2013 | 8 | 6 | 14 |
2014 | 3 | 4 | 7 |
2015 | 5 | 7 | 12 |
2016 | 3 | 6 | 9 |
2017 | 6 | 2 | 8 |
2018 | 4 | 10 | 14 |
2019 | 8 | 9 | 17 |
2020 | 6 | 8 | 14 |
2021 | 6 | 3 | 9 |
2022 | 0 | 8 | 8 |
2023 | 1 | 4 | 5 |
Below are the most recent publications written about "Presenilin-1" by people in Profiles.
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Depressive symptoms and hippocampal volume in autosomal dominant Alzheimer's disease. Alzheimers Dement. 2024 Feb; 20(2):986-994.
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Human Presenilin-1 delivered by AAV9 rescues impaired ?-secretase activity, memory deficits, and neurodegeneration in Psen mutant mice. Proc Natl Acad Sci U S A. 2023 10 17; 120(42):e2306714120.
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Pathogenic variants in the Longitudinal Early-onset Alzheimer's Disease Study cohort. Alzheimers Dement. 2023 11; 19 Suppl 9:S64-S73.
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Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal-dominant Alzheimer's disease. Aging Cell. 2023 08; 22(8):e13871.
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Sex differences in blood biomarkers and cognitive performance in individuals with autosomal dominant Alzheimer's disease. Alzheimers Dement. 2023 09; 19(9):4127-4138.
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Plasma p-tau217 predicts in vivo brain pathology and cognition in autosomal dominant Alzheimer's disease. Alzheimers Dement. 2023 06; 19(6):2585-2594.
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Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer's disease brains. Alzheimers Dement. 2023 05; 19(5):1785-1799.
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Targeting PSEN1 by lnc-CYP3A43-2/miR-29b-2-5p to Reduce ß Amyloid Plaque Formation and Improve Cognition Function. Int J Mol Sci. 2022 Sep 11; 23(18).
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White matter hyperintensities are a prominent feature of autosomal dominant Alzheimer's disease that emerge prior to dementia. Alzheimers Res Ther. 2022 06 29; 14(1):89.
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Amyloid-ß and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer's disease. Proc Natl Acad Sci U S A. 2022 04 12; 119(15):e2113641119.