Cyclin-Dependent Kinase Inhibitor p27

"Cyclin-Dependent Kinase Inhibitor p27" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cyclin-dependent kinase inhibitor that coordinates the activation of CYCLIN and CYCLIN-DEPENDENT KINASES during the CELL CYCLE. It interacts with active CYCLIN D complexed to CYCLIN-DEPENDENT KINASE 4 in proliferating cells, while in arrested cells it binds and inhibits CYCLIN E complexed to CYCLIN-DEPENDENT KINASE 2.

Descriptor ID

D050760

MeSH Number(s)

D12.644.360.225.600

D12.776.167.187.600

D12.776.476.225.600

D12.776.624.776.355.600

Concept/Terms

Cyclin-Dependent Kinase Inhibitor p27

Below are MeSH descriptors whose meaning is more general than "Cyclin-Dependent Kinase Inhibitor p27".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Cyclin-Dependent Kinase Inhibitor Proteins [D12.644.360.225]
Cyclin-Dependent Kinase Inhibitor p27 [D12.644.360.225.600]
Proteins [D12.776]
Cell Cycle Proteins [D12.776.167]
Cyclin-Dependent Kinase Inhibitor Proteins [D12.776.167.187]
Cyclin-Dependent Kinase Inhibitor p27 [D12.776.167.187.600]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Cyclin-Dependent Kinase Inhibitor Proteins [D12.776.476.225]
Cyclin-Dependent Kinase Inhibitor p27 [D12.776.476.225.600]
Neoplasm Proteins [D12.776.624]
Tumor Suppressor Proteins [D12.776.624.776]
Cyclin-Dependent Kinase Inhibitor Proteins [D12.776.624.776.355]
Cyclin-Dependent Kinase Inhibitor p27 [D12.776.624.776.355.600]

Below are MeSH descriptors whose meaning is related to "Cyclin-Dependent Kinase Inhibitor p27".

Below are MeSH descriptors whose meaning is more specific than "Cyclin-Dependent Kinase Inhibitor p27".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cyclin-Dependent Kinase Inhibitor p27" by people in Harvard Catalyst Profiles by year, and whether "Cyclin-Dependent Kinase Inhibitor p27" was a major or minor topic of these publication.

Bar chart showing 226 publications over 30 distinct years, with a maximum of 19 publications in 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	3	3
1995	0	5	5
1996	0	3	3
1997	0	8	8
1998	0	15	15
1999	0	5	5
2000	0	18	18
2001	0	16	16
2002	0	19	19
2003	0	14	14
2004	0	10	10
2005	2	10	12
2006	4	6	10
2007	3	3	6
2008	5	7	12
2009	4	8	12
2010	6	3	9
2011	2	5	7
2012	3	5	8
2013	5	3	8
2014	1	3	4
2015	1	3	4
2016	0	3	3
2017	1	2	3
2018	3	2	5
2019	2	0	2
2020	0	1	1
2021	0	2	2
2022	0	1	1
2023	0	1	1

Below are the most recent publications written about "Cyclin-Dependent Kinase Inhibitor p27" by people in Profiles.

Cells use multiple mechanisms for cell-cycle arrest upon withdrawal of individual amino acids. Cell Rep. 2023 12 26; 42(12):113539.

View in: PubMed
Cancer cell cycle dystopia: heterogeneity, plasticity, and therapy. Trends Cancer. 2022 09; 8(9):711-725.

View in: PubMed
Restoring order at the cell cycle border: Co-targeting CDK4/6 and CDK2. Cancer Cell. 2021 10 11; 39(10):1302-1305.

View in: PubMed
NP-ALT, a Liposomal:Peptide Drug, Blocks p27Kip1 Phosphorylation to Induce Oxidative Stress, Necroptosis, and Regression in Therapy-Resistant Breast Cancer Cells. Mol Cancer Res. 2021 11; 19(11):1929-1945.

View in: PubMed
Cell Line-Specific Network Models of ER+ Breast Cancer Identify Potential PI3Ka Inhibitor Resistance Mechanisms and Drug Combinations. Cancer Res. 2021 09 01; 81(17):4603-4617.

View in: PubMed
Restoring MLL reactivates latent tumor suppression-mediated vulnerability to proteasome inhibitors. Oncogene. 2020 09; 39(36):5888-5901.

View in: PubMed
MAPKAPK2 plays a crucial role in the progression of head and neck squamous cell carcinoma by regulating transcript stability. J Exp Clin Cancer Res. 2019 Apr 25; 38(1):175.

View in: PubMed
Deletion of Cdkn1b in ACI rats leads to increased proliferation and pregnancy-associated changes in the mammary gland due to perturbed systemic endocrine environment. PLoS Genet. 2019 03; 15(3):e1008002.

View in: PubMed
p27 transcriptionally coregulates cJun to drive programs of tumor progression. Proc Natl Acad Sci U S A. 2019 04 02; 116(14):7005-7014.

View in: PubMed
The anticancer effects of pharmacological inhibition of autophagy in acute erythroid leukemia cells. Anticancer Drugs. 2018 11; 29(10):944-955.

View in: PubMed

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