"alpha-Mannosidase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS.
Concept/Terms
alpha-Mannosidase- alpha-Mannosidase
- alpha Mannosidase
- alpha-D-Mannoside Mannohydrolase
- Mannohydrolase, alpha-D-Mannoside
- alpha D Mannoside Mannohydrolase
- Neutral alpha-Mannosidase
- Neutral alpha Mannosidase
- alpha-Mannosidase, Neutral
- alpha-D-Mannosidase
- alpha D Mannosidase
Lysosomal alpha-Mannosidase- Lysosomal alpha-Mannosidase
- Lysosomal alpha Mannosidase
- alpha-Mannosidase, Lysosomal
- LAMAN
- alpha Mannosidase B
- Mannosidase B, alpha
Below are MeSH descriptors whose meaning is more general than "alpha-Mannosidase".
Below are MeSH descriptors whose meaning is more specific than "alpha-Mannosidase".
This graph shows the total number of publications written about "alpha-Mannosidase" by people in Harvard Catalyst Profiles by year, and whether "alpha-Mannosidase" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1995 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 1 | 1 | 2 |
| 2020 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
Below are the most recent publications written about "alpha-Mannosidase" by people in Profiles.
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Impaired catabolism of free oligosaccharides due to MAN2C1 variants causes a neurodevelopmental disorder. Am J Hum Genet. 2022 02 03; 109(2):345-360.
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Inhibition of MAN2A1 Enhances the Immune Response to Anti-PD-L1 in Human Tumors. Clin Cancer Res. 2020 11 15; 26(22):5990-6002.
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Defining a new immune deficiency syndrome: MAN2B2-CDG. J Allergy Clin Immunol. 2020 03; 145(3):1008-1011.
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Whole exome sequencing in childhood-onset lupus frequently detects single gene etiologies. Pediatr Rheumatol Online J. 2019 Jul 30; 17(1):52.
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Origin of a-mannosidase activity in CSF. Int J Biochem Cell Biol. 2017 06; 87:34-37.
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Ancient Haplotypes at the 15q24.2 Microdeletion Region Are Linked to Brain Expression of MAN2C1 and Children's Intelligence. PLoS One. 2016; 11(6):e0157739.
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Genome-wide study of percent emphysema on computed tomography in the general population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study. Am J Respir Crit Care Med. 2014 Feb 15; 189(4):408-18.
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MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis. Brain. 2013 Jun; 136(Pt 6):1778-82.
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Deciphering the role of CD1e protein in mycobacterial phosphatidyl-myo-inositol mannosides (PIM) processing for presentation by CD1b to T lymphocytes. J Biol Chem. 2012 Sep 07; 287(37):31494-502.
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A Drosophila metallophosphoesterase mediates deglycosylation of rhodopsin. EMBO J. 2011 Jul 29; 30(18):3701-13.