Inositol 1,4,5-Trisphosphate
"Inositol 1,4,5-Trisphosphate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin.
MeSH Number(s)
D02.033.800.519.400.350
D09.853.519.400.350
D09.894.480.350
Concept/Terms
Inositol 1,4,5-Trisphosphate- Inositol 1,4,5-Trisphosphate
- Inositol 1,4,5-Triphosphate
- Myoinositol 1,4,5-Triphosphate
- 1,4,5-InsP3
- 1,4,5-IP3
- Myo-Inositol 1,4,5-Trisphosphate
Below are MeSH descriptors whose meaning is more general than "Inositol 1,4,5-Trisphosphate".
Below are MeSH descriptors whose meaning is more specific than "Inositol 1,4,5-Trisphosphate".
This graph shows the total number of publications written about "Inositol 1,4,5-Trisphosphate" by people in Harvard Catalyst Profiles by year, and whether "Inositol 1,4,5-Trisphosphate" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 3 | 4 |
| 1995 | 3 | 11 | 14 |
| 1996 | 1 | 3 | 4 |
| 1997 | 2 | 3 | 5 |
| 1998 | 0 | 3 | 3 |
| 1999 | 1 | 3 | 4 |
| 2001 | 0 | 1 | 1 |
| 2002 | 2 | 1 | 3 |
| 2003 | 1 | 1 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 1 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 2 | 3 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 2 | 3 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 2 | 3 |
| 2016 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
Below are the most recent publications written about "Inositol 1,4,5-Trisphosphate" by people in Profiles.
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Cx43 channels and signaling via IP3/Ca2+, ATP, and ROS/NO propagate radiation-induced DNA damage to non-irradiated brain microvascular endothelial cells. Cell Death Dis. 2020 03 18; 11(3):194.
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Evidence that Orai1 does not contribute to store-operated TRPC1 channels in vascular smooth muscle cells. Channels (Austin). 2017 Jul 04; 11(4):329-339.
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IP3 accumulation and/or inositol depletion: two downstream lithium's effects that may mediate its behavioral and cellular changes. Transl Psychiatry. 2016 12 06; 6(12):e968.
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The G protein a subunit variant XLas promotes inositol 1,4,5-trisphosphate signaling and mediates the renal actions of parathyroid hormone in vivo. Sci Signal. 2015 Aug 25; 8(391):ra84.
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Phospholipase C epsilon (PLCe) induced TRPC6 activation: a common but redundant mechanism in primary podocytes. J Cell Physiol. 2015 Jun; 230(6):1389-99.
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Actions of the small molecule ligands SW106 and AH-3960 on the type-1 parathyroid hormone receptor. Mol Endocrinol. 2015 Feb; 29(2):307-21.
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Preparation and use of sea urchin egg homogenates for studying NAADP-mediated Ca²? release. Cold Spring Harb Protoc. 2014 Sep 02; 2014(9):988-92.
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IP3-mediated STIM1 oligomerization requires intact mitochondrial Ca2+ uptake. J Cell Sci. 2014 Jul 01; 127(Pt 13):2944-55.
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Phosphorylated K-Ras limits cell survival by blocking Bcl-xL sensitization of inositol trisphosphate receptors. Proc Natl Acad Sci U S A. 2013 Dec 17; 110(51):20593-8.
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Calcium sensing receptor expression in ovine amniotic fluid mesenchymal stem cells and the potential role of R-568 during osteogenic differentiation. PLoS One. 2013; 8(9):e73816.