HIV Envelope Protein gp41

"HIV Envelope Protein gp41" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Transmembrane envelope protein of the HUMAN IMMUNODEFICIENCY VIRUS which is encoded by the HIV env gene. It has a molecular weight of 41,000 and is glycosylated. The N-terminal part of gp41 is thought to be involved in CELL FUSION with the CD4 ANTIGENS of T4 LYMPHOCYTES, leading to syncytial formation. Gp41 is one of the most common HIV antigens detected by IMMUNOBLOTTING.

Descriptor ID

D015700

MeSH Number(s)

D12.776.543.512.500.330

D12.776.964.775.325.164.200

D12.776.964.775.562.500.200

D12.776.964.970.880.325.164.200

D12.776.964.970.880.910.330

D23.050.327.520.330

Concept/Terms

HIV Envelope Protein gp41

Below are MeSH descriptors whose meaning is more general than "HIV Envelope Protein gp41".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Membrane Fusion Proteins [D12.776.543.512]
Viral Fusion Proteins [D12.776.543.512.500]
HIV Envelope Protein gp41 [D12.776.543.512.500.330]
Viral Proteins [D12.776.964]
Retroviridae Proteins [D12.776.964.775]
Gene Products, env [D12.776.964.775.325]
env Gene Products, Human Immunodeficiency Virus [D12.776.964.775.325.164]
HIV Envelope Protein gp41 [D12.776.964.775.325.164.200]
Human Immunodeficiency Virus Proteins [D12.776.964.775.562]
env Gene Products, Human Immunodeficiency Virus [D12.776.964.775.562.500]
HIV Envelope Protein gp41 [D12.776.964.775.562.500.200]
Viral Structural Proteins [D12.776.964.970]
Viral Envelope Proteins [D12.776.964.970.880]
Gene Products, env [D12.776.964.970.880.325]
env Gene Products, Human Immunodeficiency Virus [D12.776.964.970.880.325.164]
HIV Envelope Protein gp41 [D12.776.964.970.880.325.164.200]
Viral Fusion Proteins [D12.776.964.970.880.910]
HIV Envelope Protein gp41 [D12.776.964.970.880.910.330]
Biological Factors [D23]
Antigens [D23.050]
Antigens, Viral [D23.050.327]
HIV Antigens [D23.050.327.520]
HIV Envelope Protein gp41 [D23.050.327.520.330]

Below are MeSH descriptors whose meaning is related to "HIV Envelope Protein gp41".

Below are MeSH descriptors whose meaning is more specific than "HIV Envelope Protein gp41".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "HIV Envelope Protein gp41" by people in Harvard Catalyst Profiles by year, and whether "HIV Envelope Protein gp41" was a major or minor topic of these publication.

Bar chart showing 194 publications over 30 distinct years, with a maximum of 15 publications in 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	6	3	9
1995	1	0	1
1996	2	4	6
1997	2	2	4
1998	1	3	4
1999	1	2	3
2000	4	2	6
2001	5	2	7
2002	1	0	1
2003	4	2	6
2004	3	6	9
2005	11	0	11
2006	13	2	15
2007	3	1	4
2008	5	2	7
2009	6	5	11
2010	7	4	11
2011	6	2	8
2012	3	2	5
2013	7	1	8
2014	5	0	5
2015	3	6	9
2016	6	0	6
2017	7	0	7
2018	2	4	6
2019	4	1	5
2020	5	5	10
2021	1	1	2
2022	0	4	4
2023	2	2	4

Below are the most recent publications written about "HIV Envelope Protein gp41" by people in Profiles.

Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility. Nat Commun. 2023 11 08; 14(1):7218.

View in: PubMed
Alterations in gp120 glycans or the gp41 fusion peptide-proximal region modulate the stability of the human immunodeficiency virus (HIV-1) envelope glycoprotein pretriggered conformation. J Virol. 2023 09 28; 97(9):e0059223.

View in: PubMed
Conformations of Human Immunodeficiency Virus Envelope Glycoproteins in Detergents and Styrene-Maleic Acid Lipid Particles. J Virol. 2023 06 29; 97(6):e0032723.

View in: PubMed
Asymmetric conformations of cleaved HIV-1 envelope glycoprotein trimers in styrene-maleic acid lipid nanoparticles. Commun Biol. 2023 05 18; 6(1):535.

View in: PubMed
Dynamic HIV-1 spike motion creates vulnerability for its membrane-bound tripod to antibody attack. Nat Commun. 2022 Oct 27; 13(1):6393.

View in: PubMed
Dependence on a variable residue limits the breadth of an HIV MPER neutralizing antibody, despite convergent evolution with broadly neutralizing antibodies. PLoS Pathog. 2022 09; 18(9):e1010450.

View in: PubMed
Characterization of Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein Variants Selected for Resistance to a CD4-Mimetic Compound. J Virol. 2022 09 14; 96(17):e0063622.

View in: PubMed
Global Increases in Human Immunodeficiency Virus Neutralization Sensitivity Due to Alterations in the Membrane-Proximal External Region of the Envelope Glycoprotein Can Be Minimized by Distant State 1-Stabilizing Changes. J Virol. 2022 04 13; 96(7):e0187821.

View in: PubMed
SOSIP Trimer-Specific Antibodies Isolated from a Simian-Human Immunodeficiency Virus-Infected Monkey with versus without a Pre-blocking Step with gp41. J Virol. 2022 01 26; 96(2):e0158221.

View in: PubMed
Asymmetric Structures and Conformational Plasticity of the Uncleaved Full-Length Human Immunodeficiency Virus Envelope Glycoprotein Trimer. J Virol. 2021 11 23; 95(24):e0052921.

View in: PubMed

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