Receptors, Prostaglandin E, EP1 Subtype
"Receptors, Prostaglandin E, EP1 Subtype" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subtype of prostaglandin E receptors that specifically couples to GTP-BINDING PROTEIN ALPHA SUBUNIT, GQ and the subsequently activates TYPE C PHOSPHOLIPASES. Additional evidence has shown that the receptor can act through a calcium-dependent signaling pathway.
MeSH Number(s)
D12.776.543.750.100.200.700.600.100
Concept/Terms
Receptors, Prostaglandin E, EP1 Subtype- Receptors, Prostaglandin E, EP1 Subtype
- Prostaglandin E Receptor 1
- Prostanoid Receptor EP1
- EP1, Prostanoid Receptor
- PGE Receptor, EP1 Subtype
- Prostaglandin E2 Receptor, EP1 Subtype
Below are MeSH descriptors whose meaning is more general than "Receptors, Prostaglandin E, EP1 Subtype".
Below are MeSH descriptors whose meaning is more specific than "Receptors, Prostaglandin E, EP1 Subtype".
This graph shows the total number of publications written about "Receptors, Prostaglandin E, EP1 Subtype" by people in Harvard Catalyst Profiles by year, and whether "Receptors, Prostaglandin E, EP1 Subtype" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 2 | 2 |
| 2003 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
Below are the most recent publications written about "Receptors, Prostaglandin E, EP1 Subtype" by people in Profiles.
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Inhibition of the Prostaglandin EP-1 Receptor in Periosteum Progenitor Cells Enhances Osteoblast Differentiation and Fracture Repair. Ann Biomed Eng. 2020 Mar; 48(3):927-939.
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PGE2 Receptor Subtype 1 (EP1) Regulates Mesenchymal Stromal Cell Osteogenic Differentiation by Modulating Cellular Energy Metabolism. J Cell Biochem. 2017 12; 118(12):4383-4393.
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Loss of the PGE2 receptor EP1 enhances bone acquisition, which protects against age and ovariectomy-induced impairments in bone strength. Bone. 2015 Mar; 72:92-100.
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Novel prostaglandin receptor modulators--part II: EP receptor modulators; a patent review (2002 - 2012). Expert Opin Ther Pat. 2013 Feb; 23(2):233-67.
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Prostaglandin E2 deficiency uncovers a dominant role for thromboxane A2 in house dust mite-induced allergic pulmonary inflammation. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12692-7.
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Blockade of prostaglandin E2 signaling through EP1 and EP3 receptors attenuates Flt3L-dependent dendritic cell development from hematopoietic progenitor cells. Blood. 2012 Feb 16; 119(7):1671-82.
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Phospholipase A2 superfamily members play divergent roles after spinal cord injury. FASEB J. 2011 Dec; 25(12):4240-52.
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Targeting prostaglandin E2 EP1 receptors prevents seizure-associated P-glycoprotein up-regulation. J Pharmacol Exp Ther. 2009 Sep; 330(3):939-47.
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RhoA/Rho kinase signaling in the cumulus mediates extracellular matrix assembly. Endocrinology. 2009 Jul; 150(7):3345-52.
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Prostaglandin E2-EP1 and EP2 receptor signaling promotes apical junctional complex disassembly of Caco-2 human colorectal cancer cells. BMC Cell Biol. 2008 Dec 02; 9:63.