Mechlorethamine

"Mechlorethamine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A vesicant and necrotizing irritant destructive to mucous membranes. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage.

Descriptor ID

D008466

MeSH Number(s)

D02.455.526.728.650.529

Concept/Terms

Mechlorethamine

Cloramin

Embichin

Mechlorethamine Hydrochloride

Mechlorethamine Hydrochloride N-Oxide

NSC-762

Mechlorethamine Oxide

Mechlorethamine N-Oxide

Below are MeSH descriptors whose meaning is more general than "Mechlorethamine".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Hydrocarbons [D02.455]
Hydrocarbons, Halogenated [D02.455.526]
Mustard Compounds [D02.455.526.728]
Nitrogen Mustard Compounds [D02.455.526.728.650]
Mechlorethamine [D02.455.526.728.650.529]

Below are MeSH descriptors whose meaning is related to "Mechlorethamine".

Below are MeSH descriptors whose meaning is more specific than "Mechlorethamine".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Mechlorethamine" by people in Harvard Catalyst Profiles by year, and whether "Mechlorethamine" was a major or minor topic of these publication.

Bar chart showing 34 publications over 19 distinct years, with a maximum of 3 publications in 1994 and 1997 and 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	3	3
1995	0	2	2
1996	0	2	2
1997	0	3	3
1998	0	2	2
2000	0	1	1
2001	0	2	2
2003	1	1	2
2004	1	2	3
2006	0	1	1
2008	0	1	1
2009	0	2	2
2013	1	0	1
2014	0	2	2
2015	0	1	1
2016	0	2	2
2018	1	0	1
2020	1	0	1
2023	0	2	2

Below are the most recent publications written about "Mechlorethamine" by people in Profiles.

Insights into mustard gas keratopathy- characterizing corneal layer-specific changes in mice exposed to nitrogen mustard. Exp Eye Res. 2023 11; 236:109657.

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Mustard Gas Exposure Actuates SMAD2/3 Signaling to Promote Myofibroblast Generation in the Cornea. Cells. 2023 06 02; 12(11).

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Cutaneous Langerhans Cell Histiocytosis Responsive to Topical Nitrogen Mustard. J Drugs Dermatol. 2020 Aug 01; 19(8):803-805.

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Valchlor maintenance therapy for patients with mycosis fungoides who received low dose total skin electron beam treatment. Chin Clin Oncol. 2019 Feb; 8(1):13.

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PD-L1 and PD-L2 Genetic Alterations Define Classical Hodgkin Lymphoma and Predict Outcome. J Clin Oncol. 2016 08 10; 34(23):2690-7.

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Combination chemotherapy of solid tumors: an American-Italian collaboration: a celebration of the work of Gianni Bonadonna. Tumori. 2016 Mar-Apr; 102(2):124-6.

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Suppression of Hyperactive Immune Responses Protects against Nitrogen Mustard Injury. J Invest Dermatol. 2015 Dec; 135(12):2971-2981.

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Fifty years from Paris: the remarkable story of the lymphomas. Int J Radiat Oncol Biol Phys. 2015 May 01; 92(1):1-2.

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Randomized Phase III Trial Comparing ABVD Plus Radiotherapy With the Stanford V Regimen in Patients With Stages I or II Locally Extensive, Bulky Mediastinal Hodgkin Lymphoma: A Subset Analysis of the North American Intergroup E2496 Trial. J Clin Oncol. 2015 Jun 10; 33(17):1936-42.

View in: PubMed
Thyroid malignancies in survivors of Hodgkin lymphoma. Int J Radiat Oncol Biol Phys. 2014 Mar 01; 88(3):636-41.

View in: PubMed

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