Isocoumarins

"Isocoumarins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Compounds that differ from COUMARINS in having the positions of the ring and ketone oxygens reversed so the keto oxygen is at the 1-position of the molecule.

Descriptor ID

D049934

MeSH Number(s)

D03.438.150.446.598

D03.830.219.446.598

Concept/Terms

Isocoumarins

Below are MeSH descriptors whose meaning is more general than "Isocoumarins".

Chemicals and Drugs [D]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, 2-Ring [D03.438]
Benzopyrans [D03.438.150]
Coumarins [D03.438.150.446]
Isocoumarins [D03.438.150.446.598]
Pyrans [D03.830]
Benzopyrans [D03.830.219]
Coumarins [D03.830.219.446]
Isocoumarins [D03.830.219.446.598]

Below are MeSH descriptors whose meaning is related to "Isocoumarins".

Below are MeSH descriptors whose meaning is more specific than "Isocoumarins".

Isocoumarins
Ochratoxins

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Isocoumarins" by people in Harvard Catalyst Profiles by year, and whether "Isocoumarins" was a major or minor topic of these publication.

Bar chart showing 13 publications over 12 distinct years, with a maximum of 2 publications in 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
2000	0	1	1
2001	0	1	1
2002	0	1	1
2004	0	1	1
2005	1	0	1
2006	1	1	2
2012	1	0	1
2014	1	0	1
2017	1	0	1
2021	1	0	1
2022	1	0	1

Below are the most recent publications written about "Isocoumarins" by people in Profiles.

Fe(III)-catalyzed regioselective and faster synthesis of isocoumarins with 3-oxoalkyl moiety at C-4: Identification of new inhibitors of PDE4. Bioorg Chem. 2022 04; 121:105667.

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PdCl2-catalyzed synthesis of a new class of isocoumarin derivatives containing aminosulfonyl / aminocarboxamide moiety: First identification of a isocoumarin based PDE4 inhibitor. Eur J Med Chem. 2021 Oct 05; 221:113514.

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Isolation of a phytotoxic isocoumarin from Diaporthe eres-infected Hedera helix (English ivy) and synthesis of its phytotoxic analogs. Pest Manag Sci. 2018 Jan; 74(1):37-45.

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Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy. Science. 2014 Aug 08; 345(6197):688-93.

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Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin. Cell Host Microbe. 2012 Jun 14; 11(6):654-63.

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Regiocontrolled intramolecular cyclizations of carboxylic acids to carbon-carbon triple bonds promoted by acid or base catalyst. Org Lett. 2006 Nov 23; 8(24):5517-20.

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A novel isocoumarin derivative induces mitotic phase arrest and apoptosis of human multiple myeloma cells. Cancer Chemother Pharmacol. 2007 Feb; 59(3):329-35.

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2-(8-hydroxy-6-methoxy-1-oxo-1h-2-benzopyran-3-yl) propionic acid, an inhibitor of angiogenesis, ameliorates renal alterations in obese type 2 diabetic mice. Diabetes. 2006 May; 55(5):1232-42.

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The angiogenesis inhibitor NM-3 is active against human NSCLC xenografts alone and in combination with docetaxel. Cancer Chemother Pharmacol. 2005 Dec; 56(6):610-4.

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2-(8-Hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-yl)propionic acid, a small molecule isocoumarin, potentiates dexamethasone-induced apoptosis of human multiple myeloma cells. Cancer Res. 2004 Dec 01; 64(23):8512-6.

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