Caspase 7

"Caspase 7" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 3 and CASPASE 10. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.

Descriptor ID

D053179

MeSH Number(s)

D08.811.277.656.262.500.126.350.700

D08.811.277.656.300.200.126.350.700

D12.644.360.075.405.350.700

D12.776.476.075.405.350.700

Concept/Terms

Caspase 7

Procaspase 7

Below are MeSH descriptors whose meaning is more general than "Caspase 7".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Peptide Hydrolases [D08.811.277.656]
Cysteine Proteases [D08.811.277.656.262]
Cysteine Endopeptidases [D08.811.277.656.262.500]
Caspases [D08.811.277.656.262.500.126]
Caspases, Effector [D08.811.277.656.262.500.126.350]
Caspase 7 [D08.811.277.656.262.500.126.350.700]
Endopeptidases [D08.811.277.656.300]
Cysteine Endopeptidases [D08.811.277.656.300.200]
Caspases [D08.811.277.656.300.200.126]
Caspases, Effector [D08.811.277.656.300.200.126.350]
Caspase 7 [D08.811.277.656.300.200.126.350.700]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Apoptosis Regulatory Proteins [D12.644.360.075]
Caspases [D12.644.360.075.405]
Caspases, Effector [D12.644.360.075.405.350]
Caspase 7 [D12.644.360.075.405.350.700]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Apoptosis Regulatory Proteins [D12.776.476.075]
Caspases [D12.776.476.075.405]
Caspases, Effector [D12.776.476.075.405.350]
Caspase 7 [D12.776.476.075.405.350.700]

Below are MeSH descriptors whose meaning is related to "Caspase 7".

Below are MeSH descriptors whose meaning is more specific than "Caspase 7".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Caspase 7" by people in Harvard Catalyst Profiles by year, and whether "Caspase 7" was a major or minor topic of these publication.

Bar chart showing 42 publications over 19 distinct years, with a maximum of 5 publications in 2011 and 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
1998	0	1	1
1999	0	1	1
2001	0	1	1
2003	0	2	2
2004	0	1	1
2005	0	1	1
2007	0	2	2
2008	1	1	2
2009	2	1	3
2010	0	4	4
2011	2	3	5
2012	0	2	2
2013	0	3	3
2014	0	3	3
2015	1	1	2
2016	0	5	5
2017	0	1	1
2022	0	2	2

Below are the most recent publications written about "Caspase 7" by people in Profiles.

Role of Caspases and Gasdermin A during HSV-1 Infection in Mice. Viruses. 2022 09 13; 14(9).

View in: PubMed
Clostridioides difficile toxin B alone and with pro-inflammatory cytokines induces apoptosis in enteric glial cells by activating three different signalling pathways mediated by caspases, calpains and cathepsin B. Cell Mol Life Sci. 2022 Jul 22; 79(8):442.

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Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis. Nat Commun. 2018 11 19; 9(1):4846.

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Mesenchymal stem cell (MSC)-mediated survival of insulin producing pancreatic ß-cells during cellular stress involves signalling via Akt and ERK1/2. Mol Cell Endocrinol. 2018 09 15; 473:235-244.

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Mutations of KIF14 cause primary microcephaly by impairing cytokinesis. Ann Neurol. 2017 Oct; 82(4):562-577.

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Combined CDK4/6 and mTOR Inhibition Is Synergistic against Glioblastoma via Multiple Mechanisms. Clin Cancer Res. 2017 Nov 15; 23(22):6958-6968.

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Cathepsin L silencing increases As2O3 toxicity in malignantly transformed pilocytic astrocytoma MPA58 cells by activating caspases 3/7. Exp Cell Res. 2017 07 01; 356(1):64-73.

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Selenium supplementation modulates apoptotic processes in thyroid follicular cells. Biofactors. 2017 May 06; 43(3):415-423.

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Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding. J Biol Chem. 2017 03 24; 292(12):4885-4897.

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Suppressors of Superoxide-H2O2 Production at Site IQ of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury. Cell Metab. 2016 10 11; 24(4):582-592.

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