D004789PhysiologyG02.111.087.245G02.149.115.245G03.495.368139537010.617651Enzyme Activationcatalyst:eCommonsLogineCommons LoginFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:meshTreeNumberMeSH tree numberprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierDepartmentDivisionvivo:hrJobTitleHR job titleInformation ResourcePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlevivo:researchAreaOfresearch area ofvivo:subjectAreaForsubject area forrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson30573704Farese RV, Sajan MPAgingAtypical PKC: therapeutic target for Alzheimer's? Aging (Albany NY). 2018 12 20; 11(1):13-14.Aging (Albany NY)2018-12-20T00:00:002018Atypical PKC: therapeutic target for Alzheimer's?1.574190.00106971395research area of0.9741510.005724654913subject area forMedicineOphthalmologyCardiologyAdult OncologyJoslinBrigham and Women's HospitalDana-Farber Cancer InstituteJoslin Diabetes CenterSchepens Eye Research InstituteDAD1DarleneDarttDarlene Ann Dartt, Ph.D.42.36200000000000-71.0644000000000016919Dartt, DarleneProfessor of OphthalmologyTMM3ThomasMichelThomas Michel, M.D., Ph.D.42.33510370000000-71.1061649000000085444Michel, ThomasProfessor of MedicineLJG1LaurieGoodyearLaurie Joy Goodyear, Ph.D.42.33839600000000-71.1084030000000025240Goodyear, LaurieProfessor of MedicineDWK1DonaldKufeDonald William Kufe, M.D.42.33789600000000-71.1072493000000033740Kufe, DonaldProfessor of MedicineGLK1GeorgeKingGeorge Liang King, M.D.42.33839600000000-71.1084030000000068100King, GeorgeThomas J. Beatson, Jr. Professor of Medicine in the Field of Diabetestrue1Professor of OphthalmologyProfessor of Ophthalmologytrue1Professor of MedicineProfessor of Medicinetrue1Professor of MedicineProfessor of Medicine34510420Vassiliou D, Sardh E, Harper P, Simon AR, Clausen VA, Najafian N, Robbie GJ, Agarwal SClinical pharmacology and therapeuticsA Drug-Drug Interaction Study Evaluating the Effect of Givosiran, a Small Interfering Ribonucleic Acid, on Cytochrome P450 Activity in the Liver. Clin Pharmacol Ther. 2021 11; 110(5):1250-1260.Clin Pharmacol Ther2021-09-28T00:00:002021A Drug-Drug Interaction Study Evaluating the Effect of Givosiran, a Small Interfering Ribonucleic Acid, on Cytochrome P450 Activity in the Liver.32681076Scheuermann U, Seyferth ER, Abraham N, Kesseli SJ, Halpern SE, Zhu M, Song M, Hartwig MG, Parker W, Kwun J, Cherry AD, Lee J, Barbas ASScientific reportsSirtuin-1 expression and activity is diminished in aged liver grafts. Sci Rep. 2020 07 17; 10(1):11860.Sci Rep2020-07-17T00:00:002020Sirtuin-1 expression and activity is diminished in aged liver grafts.30191648Fischer TH, Eiringhaus J, Dybkova N, Saadatmand A, Pabel S, Weber S, Wang Y, Köhn M, Tirilomis T, Ljubojevic S, Renner A, Gummert J, Maier LS, Hasenfuß G, El-Armouche A, Sossalla SEuropean journal of heart failureActivation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca2+ leak in human heart failure. Eur J Heart Fail. 2018 12; 20(12):1673-1685.Eur J Heart Fail2018-09-07T00:00:002018Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca2+ leak in human heart failure.true1Thomas J. Beatson, Jr. Professor of Medicine in the Field of DiabetesThomas J. Beatson, Jr. Professor of Medicine in the Field of Diabetestrue1Professor of MedicineProfessor of Medicine37949226Petrova B, Maynard AG, Wang P, Kanarek NThe Journal of biological chemistryRegulatory mechanisms of one-carbon metabolism enzymes. J Biol Chem. 2023 Dec; 299(12):105457.J Biol Chem2023-11-09T00:00:002023Regulatory mechanisms of one-carbon metabolism enzymes.0Full Professor