Phosphatidic Acids

"Phosphatidic Acids" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Fatty acid derivatives of glycerophosphates. They are composed of glycerol bound in ester linkage with 1 mole of phosphoric acid at the terminal 3-hydroxyl group and with 2 moles of fatty acids at the other two hydroxyl groups.

Descriptor ID

D010712

MeSH Number(s)

D10.570.755.375.760

Concept/Terms

Phosphatidic Acids

Diacylglycerophosphates

Ammonium Phosphatidate

Phosphatidic Acid

Below are MeSH descriptors whose meaning is more general than "Phosphatidic Acids".

Chemicals and Drugs [D]
Lipids [D10]
Membrane Lipids [D10.570]
Phospholipids [D10.570.755]
Glycerophosphates [D10.570.755.375]
Phosphatidic Acids [D10.570.755.375.760]

Below are MeSH descriptors whose meaning is related to "Phosphatidic Acids".

Below are MeSH descriptors whose meaning is more specific than "Phosphatidic Acids".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Phosphatidic Acids" by people in Harvard Catalyst Profiles by year, and whether "Phosphatidic Acids" was a major or minor topic of these publication.

Bar chart showing 23 publications over 18 distinct years, with a maximum of 2 publications in 1997 and 2003 and 2008 and 2010 and 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	1	1
1995	0	1	1
1997	0	2	2
1998	0	1	1
2000	0	1	1
2001	0	1	1
2003	1	1	2
2004	0	1	1
2007	0	1	1
2008	1	1	2
2010	2	0	2
2012	0	1	1
2013	1	0	1
2015	1	0	1
2017	0	1	1
2019	2	0	2
2020	0	1	1
2021	0	1	1

Below are the most recent publications written about "Phosphatidic Acids" by people in Profiles.

Direct binding of ESCRT protein Chm7 to phosphatidic acid-rich membranes at nuclear envelope herniations. J Cell Biol. 2021 03 01; 220(3).

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Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex. Cancer Res. 2021 04 15; 81(8):2086-2100.

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Phospholipase D1 Ablation Disrupts Mouse Longitudinal Hippocampal Axis Organization and Functioning. Cell Rep. 2020 03 24; 30(12):4197-4208.e6.

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Phosphatidic acid drives mTORC1 lysosomal translocation in the absence of amino acids. J Biol Chem. 2020 01 03; 295(1):263-274.

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A small-molecule competitive inhibitor of phosphatidic acid binding by the AAA+ protein NSF/Sec18 blocks the SNARE-priming stage of vacuole fusion. J Biol Chem. 2019 11 15; 294(46):17168-17185.

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The late stage of COPI vesicle fission requires shorter forms of phosphatidic acid and diacylglycerol. Nat Commun. 2019 07 30; 10(1):3409.

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Phosphatidic acid induces conformational changes in Sec18 protomers that prevent SNARE priming. J Biol Chem. 2019 03 01; 294(9):3100-3116.

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A Molecular Target for an Alcohol Chain-Length Cutoff. J Mol Biol. 2019 01 18; 431(2):196-209.

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The phosphatidic acid-binding, polybasic domain is responsible for the differences in the phosphoregulation of lipins 1 and 3. J Biol Chem. 2017 12 15; 292(50):20481-20493.

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Lipidomic Adaptations in White and Brown Adipose Tissue in Response to Exercise Demonstrate Molecular Species-Specific Remodeling. Cell Rep. 2017 02 07; 18(6):1558-1572.

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