Signal Recognition Particle

"Signal Recognition Particle" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cytosolic ribonucleoprotein complex that acts to induce elongation arrest of nascent presecretory and membrane proteins until the ribosome becomes associated with the rough endoplasmic reticulum. It consists of a 7S RNA and at least six polypeptide subunits (relative molecular masses 9, 14, 19, 54, 68, and 72K).

Descriptor ID

D018271

MeSH Number(s)

D12.776.157.725.500.750.800

D12.776.664.962.500.750.800

Concept/Terms

Signal Recognition Particle

Below are MeSH descriptors whose meaning is more general than "Signal Recognition Particle".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
RNA-Binding Proteins [D12.776.157.725]
Ribonucleoproteins [D12.776.157.725.500]
Ribonucleoproteins, Small Cytoplasmic [D12.776.157.725.500.750]
Signal Recognition Particle [D12.776.157.725.500.750.800]
Nucleoproteins [D12.776.664]
RNA-Binding Proteins [D12.776.664.962]
Ribonucleoproteins [D12.776.664.962.500]
Ribonucleoproteins, Small Cytoplasmic [D12.776.664.962.500.750]
Signal Recognition Particle [D12.776.664.962.500.750.800]

Below are MeSH descriptors whose meaning is related to "Signal Recognition Particle".

Below are MeSH descriptors whose meaning is more specific than "Signal Recognition Particle".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Signal Recognition Particle" by people in Harvard Catalyst Profiles by year, and whether "Signal Recognition Particle" was a major or minor topic of these publication.

Bar chart showing 21 publications over 14 distinct years, with a maximum of 3 publications in 2000

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
1996	1	0	1
1998	2	0	2
2000	1	2	3
2002	1	0	1
2003	1	1	2
2005	1	1	2
2006	0	1	1
2014	1	0	1
2015	1	1	2
2016	1	0	1
2017	1	0	1
2018	1	0	1
2020	0	2	2

Below are the most recent publications written about "Signal Recognition Particle" by people in Profiles.

Human mutational constraint as a tool to understand biology of rare and emerging bone marrow failure syndromes. Blood Adv. 2020 10 27; 4(20):5232-5245.

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The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis. Nat Commun. 2020 05 26; 11(1):2619.

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Development of Necrotizing Myopathy Following Interstitial Lung Disease with Anti-signal Recognition Particle Antibody. Intern Med. 2018 Jul 15; 57(14):2045-2049.

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Mutations in signal recognition particle SRP54 cause syndromic neutropenia with Shwachman-Diamond-like features. J Clin Invest. 2017 Nov 01; 127(11):4090-4103.

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Dis3l2-Mediated Decay Is a Quality Control Pathway for Noncoding RNAs. Cell Rep. 2016 08 16; 16(7):1861-73.

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Whole transcriptome profiling reveals the RNA content of motor axons. Nucleic Acids Res. 2016 Feb 29; 44(4):e33.

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Noncanoncial signal recognition particle RNAs in a major eukaryotic phylum revealed by purification of SRP from the human pathogen Cryptococcus neoformans. Nucleic Acids Res. 2015 Oct 15; 43(18):9017-27.

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Inefficient SRP interaction with a nascent chain triggers a mRNA quality control pathway. Cell. 2014 Jan 16; 156(1-2):146-57.

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Rituximab therapy for myopathy associated with anti-signal recognition particle antibodies: a case series. Arthritis Care Res (Hoboken). 2010 Sep; 62(9):1328-34.

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Structural insights into the assembly of the human and archaeal signal recognition particles. Acta Crystallogr D Biol Crystallogr. 2010 Mar; 66(Pt 3):295-303.

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