Harvard Catalyst Profiles

Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here.

Below are MeSH descriptors whose meaning is more general than "GABA Modulators".

Below are MeSH descriptors whose meaning is related to "GABA Modulators".

Below are MeSH descriptors whose meaning is more specific than "GABA Modulators".