Asparagine

"Asparagine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)

Descriptor ID

D001216

MeSH Number(s)

D12.125.068.060

D12.125.095.165

D12.125.154.049

Concept/Terms

Asparagine

Below are MeSH descriptors whose meaning is more general than "Asparagine".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Amino Acids [D12.125]
Amino Acids, Basic [D12.125.068]
Asparagine [D12.125.068.060]
Amino Acids, Diamino [D12.125.095]
Asparagine [D12.125.095.165]
Amino Acids, Neutral [D12.125.154]
Asparagine [D12.125.154.049]

Below are MeSH descriptors whose meaning is related to "Asparagine".

Below are MeSH descriptors whose meaning is more specific than "Asparagine".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Asparagine" by people in Harvard Catalyst Profiles by year, and whether "Asparagine" was a major or minor topic of these publication.

Bar chart showing 58 publications over 26 distinct years, with a maximum of 6 publications in 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	1	1
1995	0	2	2
1997	0	1	1
1998	1	1	2
1999	1	1	2
2001	1	1	2
2002	1	3	4
2003	0	6	6
2004	0	4	4
2005	1	1	2
2006	1	0	1
2007	1	4	5
2008	0	1	1
2009	1	0	1
2010	0	2	2
2012	0	1	1
2013	1	2	3
2014	0	1	1
2015	1	0	1
2016	0	1	1
2017	1	3	4
2018	1	0	1
2019	2	2	4
2020	1	2	3
2022	0	2	2
2023	1	0	1

Below are the most recent publications written about "Asparagine" by people in Profiles.

Discovery of Highly Selective Inhibitors of the Human Constitutive Proteasome ß5c Chymotryptic Subunit. J Med Chem. 2023 01 26; 66(2):1172-1185.

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Supramolecular assembly of GSK3a as a cellular response to amino acid starvation. Mol Cell. 2022 08 04; 82(15):2858-2870.e8.

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Association of allele-specific methylation of the ASNS gene with asparaginase sensitivity and prognosis in T-ALL. Blood Adv. 2022 01 11; 6(1):212-224.

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Antimetabolic cooperativity with the clinically approved l-asparaginase and tyrosine kinase inhibitors to eradicate CML stem cells. Mol Metab. 2022 01; 55:101410.

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Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell. Elife. 2020 05 28; 9.

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ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase. Cell Metab. 2020 04 07; 31(4):852-861.e6.

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Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses. Nat Commun. 2020 02 07; 11(1):791.

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Asparagine-84, a regulatory allosteric site residue, helps maintain the quaternary structure of Campylobacter jejuni dihydrodipicolinate synthase. J Struct Biol. 2020 01 01; 209(1):107409.

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Improvement of Asparagine Ethylenediamines as Anti-malarial Plasmodium-Selective Proteasome Inhibitors. J Med Chem. 2019 07 11; 62(13):6137-6145.

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The landscape of cancer cell line metabolism. Nat Med. 2019 05; 25(5):850-860.

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