Thiorphan

"Thiorphan" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.

Descriptor ID

D015244

MeSH Number(s)

D02.886.030.893

D12.125.166.893

D12.125.481.700.750

Concept/Terms

Thiorphan

Thiorphan, (R)-Isomer

Thiorphan, (S)-Isomer

Below are MeSH descriptors whose meaning is more general than "Thiorphan".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Sulfur Compounds [D02.886]
Amino Acids, Sulfur [D02.886.030]
Thiorphan [D02.886.030.893]
Amino Acids, Peptides, and Proteins [D12]
Amino Acids [D12.125]
Amino Acids, Sulfur [D12.125.166]
Thiorphan [D12.125.166.893]
Glycine [D12.125.481]
N-substituted Glycines [D12.125.481.700]
Thiorphan [D12.125.481.700.750]

Below are MeSH descriptors whose meaning is related to "Thiorphan".

Below are MeSH descriptors whose meaning is more specific than "Thiorphan".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Thiorphan" by people in Harvard Catalyst Profiles by year, and whether "Thiorphan" was a major or minor topic of these publication.

Bar chart showing 2 publications over 2 distinct years, with a maximum of 1 publications in 1999 and 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2002	1	0	1

Below are the most recent publications written about "Thiorphan" by people in Profiles.

Pivotal role of mouse mast cell protease 4 in the conversion and pressor properties of Big-endothelin-1. J Pharmacol Exp Ther. 2013 Jul; 346(1):31-7.

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Neutral endopeptidase inhibition in diabetic wound repair. Wound Repair Regen. 2002 Sep-Oct; 10(5):295-301.

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Possible involvement of placental peptidases that degrade gonadotropin-releasing hormone (GnRH) in the dynamic pattern of placental hCG secretion via GnRH degradation. Placenta. 2002 Jul; 23(6):483-9.

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Neutral endopeptidase knockout induces hyperalgesia in a model of visceral pain, an effect related to bradykinin and nitric oxide. J Mol Neurosci. 2002 Feb-Apr; 18(1-2):129-34.

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A randomized trial of ecadotril versus placebo in patients with mild to moderate heart failure: the U.S. ecadotril pilot safety study. Am Heart J. 1999 Dec; 138(6 Pt 1):1140-8.

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Targeted deletion of the neutral endopeptidase gene alters ventilatory responses to acute hypoxia in mice. J Appl Physiol (1985). 1999 Oct; 87(4):1266-71.

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Effect of the NEP inhibitor SCH32615 on airway responses to intravenous substance P in guinea pigs. J Appl Physiol (1985). 1992 Nov; 73(5):1847-53.

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Peptidase modulation of the pulmonary effects of tachykinins. Int Arch Allergy Appl Immunol. 1991; 94(1-4):325-9.

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Peptidase modulation of the pulmonary effects of tachykinins in tracheal superfused guinea pig lungs. J Clin Invest. 1990 Jan; 85(1):170-6.

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Degradative enzymes modulate airway responses to intravenous neurokinins A and B. J Appl Physiol (1985). 1989 Dec; 67(6):2504-11.

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J Appl Physiol (1985)
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