Ophthalmoplegia, Chronic Progressive External
"Ophthalmoplegia, Chronic Progressive External" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitochondrial myopathy characterized by slowly progressive paralysis of the levator palpebrae, orbicularis oculi, and extraocular muscles. Ragged-red fibers and atrophy are found on muscle biopsy. Familial and sporadic forms may occur. Disease onset is usually in the first or second decade of life, and the illness slowly progresses until usually all ocular motility is lost. (From Adams et al., Principles of Neurology, 6th ed, p1422)
MeSH Number(s)
C05.651.460.700
C10.292.562.750.250
C10.292.562.775
C10.597.622.447.511
C10.668.491.500.700
C11.590.472.250
C11.590.641
C18.452.660.560.700
C23.888.592.636.447.511
Concept/Terms
Ophthalmoplegia, Chronic Progressive External- Ophthalmoplegia, Chronic Progressive External
- Graefe Disease
- Disease, Graefe
- Mitochondrial Ocular Myopathy
- Mitochondrial Ocular Myopathies
- Myopathies, Mitochondrial Ocular
- Myopathy, Mitochondrial Ocular
- Ocular Myopathies, Mitochondrial
- Ocular Myopathy, Mitochondrial
- Progressive External Ophthalmoplegia
- Graefe's Disease
- Graefes Disease
- Ocular Myopathy of Von Graefe-Fuchs
- Ocular Myopathy of Von Graefe Fuchs
- Ophthalmoplegia, Progressive External
- External Ophthalmoplegia, Progressive
- External Ophthalmoplegias, Progressive
- Ophthalmoplegias, Progressive External
- Progressive External Ophthalmoplegias
- CPEO
- Ocular Muscular Dystrophy
- Dystrophies, Ocular Muscular
- Dystrophy, Ocular Muscular
- Muscular Dystrophies, Ocular
- Muscular Dystrophy, Ocular
- Ocular Muscular Dystrophies
Below are MeSH descriptors whose meaning is more general than "Ophthalmoplegia, Chronic Progressive External".
- Diseases [C]
- Musculoskeletal Diseases [C05]
- Muscular Diseases [C05.651]
- Mitochondrial Myopathies [C05.651.460]
- Ophthalmoplegia, Chronic Progressive External [C05.651.460.700]
- Nervous System Diseases [C10]
- Cranial Nerve Diseases [C10.292]
- Ocular Motility Disorders [C10.292.562]
- Ophthalmoplegia [C10.292.562.750]
- Ophthalmoplegia, Chronic Progressive External [C10.292.562.750.250]
- Ophthalmoplegia, Chronic Progressive External [C10.292.562.775]
- Neurologic Manifestations [C10.597]
- Paralysis [C10.597.622]
- Ophthalmoplegia [C10.597.622.447]
- Ophthalmoplegia, Chronic Progressive External [C10.597.622.447.511]
- Neuromuscular Diseases [C10.668]
- Muscular Diseases [C10.668.491]
- Mitochondrial Myopathies [C10.668.491.500]
- Ophthalmoplegia, Chronic Progressive External [C10.668.491.500.700]
- Eye Diseases [C11]
- Ocular Motility Disorders [C11.590]
- Ophthalmoplegia [C11.590.472]
- Ophthalmoplegia, Chronic Progressive External [C11.590.472.250]
- Ophthalmoplegia, Chronic Progressive External [C11.590.641]
- Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
- Mitochondrial Diseases [C18.452.660]
- Mitochondrial Myopathies [C18.452.660.560]
- Ophthalmoplegia, Chronic Progressive External [C18.452.660.560.700]
- Pathological Conditions, Signs and Symptoms [C23]
- Signs and Symptoms [C23.888]
- Neurologic Manifestations [C23.888.592]
- Paralysis [C23.888.592.636]
- Ophthalmoplegia [C23.888.592.636.447]
- Ophthalmoplegia, Chronic Progressive External [C23.888.592.636.447.511]
Below are MeSH descriptors whose meaning is more specific than "Ophthalmoplegia, Chronic Progressive External".
This graph shows the total number of publications written about "Ophthalmoplegia, Chronic Progressive External" by people in Harvard Catalyst Profiles by year, and whether "Ophthalmoplegia, Chronic Progressive External" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1999 | 1 | 0 | 1 |
| 2003 | 1 | 1 | 2 |
| 2009 | 1 | 1 | 2 |
| 2013 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 3 | 0 | 3 |
| 2020 | 0 | 1 | 1 |
Below are the most recent publications written about "Ophthalmoplegia, Chronic Progressive External" by people in Profiles.
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Severe Chronic Progressive External Ophthalmoplegia-Associated Ptosis Successfully Treated With Scleral Lenses. J Neuroophthalmol. 2021 06 01; 41(2):e189-e191.
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Severe Chronic Progressive External Ophthalmoplegia-Associated Ptosis Successfully Treated With Scleral Lenses: Response. J Neuroophthalmol. 2021 03 01; 41(1):137-138.
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Paroxysmal oculogyric dystonia associated with a de novo 3q29 microdeletion. Psychiatr Genet. 2020 08; 30(4):119-123.
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Relapsing remitting multiple sclerosis in progressive external ophthalmoplegia: A report of two cases. Mult Scler. 2019 05; 25(6):879-882.
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On the double: Early immunotherapy speeds recovery of ocular myasthenic weakness. Muscle Nerve. 2018 12; 58(6):743-744.
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Progressive fat replacement of muscle contributes to the disease mechanism of patients with single, large-scale deletions of mitochondrial DNA. Neuromuscul Disord. 2018 05; 28(5):408-413.
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A clue for familial mitochondrial disorder: Discovering a vintage painting. Neurology. 2018 02 06; 90(6):294-295.
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Focal Segmental Glomerulosclerosis Associated with Chronic Progressive External Ophthalmoplegia and Mitochondrial DNA A3243G Mutation. Nephron. 2018; 138(3):243-248.
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Clonal expansion of secondary mitochondrial DNA deletions associated with spinocerebellar ataxia type 28. JAMA Neurol. 2015 Jan; 72(1):106-11.
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Mutations in the SPG7 gene cause chronic progressive external ophthalmoplegia through disordered mitochondrial DNA maintenance. Brain. 2014 May; 137(Pt 5):1323-36.