Upstream Stimulatory Factors

"Upstream Stimulatory Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Ubiquitously expressed basic HELIX-LOOP-HELIX MOTIF transcription factors. They bind CANNTG sequences in the promoters of a variety of GENES involved in carbohydrate and lipid metabolism.

Descriptor ID

D051720

MeSH Number(s)

D12.776.260.103.937

D12.776.930.125.937

Concept/Terms

Upstream Stimulatory Factors

Below are MeSH descriptors whose meaning is more general than "Upstream Stimulatory Factors".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Basic Helix-Loop-Helix Transcription Factors [D12.776.260.103]
Upstream Stimulatory Factors [D12.776.260.103.937]
Transcription Factors [D12.776.930]
Basic Helix-Loop-Helix Transcription Factors [D12.776.930.125]
Upstream Stimulatory Factors [D12.776.930.125.937]

Below are MeSH descriptors whose meaning is related to "Upstream Stimulatory Factors".

Below are MeSH descriptors whose meaning is more specific than "Upstream Stimulatory Factors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Upstream Stimulatory Factors" by people in Harvard Catalyst Profiles by year, and whether "Upstream Stimulatory Factors" was a major or minor topic of these publication.

Bar chart showing 12 publications over 11 distinct years, with a maximum of 2 publications in 1996

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
1996	0	2	2
1997	0	1	1
1999	0	1	1
2001	0	1	1
2003	0	1	1
2008	0	1	1
2009	1	0	1
2013	0	1	1
2016	0	1	1
2020	1	0	1

Below are the most recent publications written about "Upstream Stimulatory Factors" by people in Profiles.

Transcriptional Suppression of Diabetic Nephropathy with Novel Gene Silencer Pyrrole-Imidazole Polyamides Preventing USF1 Binding to the TGF-ß1 Promoter. Int J Mol Sci. 2021 Apr 29; 22(9).

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Aberrant expression of USF2 in refractory rheumatoid arthritis and its regulation of proinflammatory cytokines in Th17 cells. Proc Natl Acad Sci U S A. 2020 12 01; 117(48):30639-30648.

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Setd1a and NURF mediate chromatin dynamics and gene regulation during erythroid lineage commitment and differentiation. Nucleic Acids Res. 2016 09 06; 44(15):7173-88.

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USF1 deficiency activates brown adipose tissue and improves cardiometabolic health. Sci Transl Med. 2016 Jan 27; 8(323):323ra13.

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The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation. Nat Immunol. 2014 Mar; 15(3):239-47.

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Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells. Int J Biochem Cell Biol. 2013 Nov; 45(11):2359-68.

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Genetic determinants of plasma triglycerides. J Lipid Res. 2011 Feb; 52(2):189-206.

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The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. PLoS Genet. 2009 Sep; 5(9):e1000637.

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Hepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytes. J Biol Chem. 2009 Oct 16; 284(42):28510-21.

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Down-regulation of hsa-miR-10a in chronic myeloid leukemia CD34+ cells increases USF2-mediated cell growth. Mol Cancer Res. 2008 Dec; 6(12):1830-40.

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