"Proguanil" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.
Concept/Terms
Proguanil Hydrochloride- Proguanil Hydrochloride
- Hydrochloride, Proguanil
- Chloroguanide Hydrochloride
- Hydrochloride, Chloroguanide
Paludrine- Paludrine
- Zeneca Brand of Chloroguanide Hydrochloride
- Paludrin
- Astra Brand of Chloroguanide Hydrochloride
- AstraZeneca Brand of Chloroguanide Hydrochloride
Below are MeSH descriptors whose meaning is more general than "Proguanil".
Below are MeSH descriptors whose meaning is more specific than "Proguanil".
This graph shows the total number of publications written about "Proguanil" by people in Harvard Catalyst Profiles by year, and whether "Proguanil" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1996 | 0 | 1 | 1 |
1998 | 1 | 0 | 1 |
2006 | 1 | 0 | 1 |
2007 | 1 | 0 | 1 |
2011 | 0 | 1 | 1 |
2015 | 1 | 0 | 1 |
2016 | 0 | 1 | 1 |
Below are the most recent publications written about "Proguanil" by people in Profiles.
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Adaptive Landscape by Environment Interactions Dictate Evolutionary Dynamics in Models of Drug Resistance. PLoS Comput Biol. 2016 Jan; 12(1):e1004710.
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Formation of the diuretic chlorazanil from the antimalarial drug proguanil--implications for sports drug testing. J Pharm Biomed Anal. 2015 Nov 10; 115:208-13.
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The diminishing returns of atovaquone-proguanil for elimination of Plasmodium falciparum malaria: modelling mass drug administration and treatment. Malar J. 2014 Sep 24; 13:380.
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Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression. J Biol Chem. 2012 Mar 23; 287(13):9731-9741.
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Fitness trade-offs in the evolution of dihydrofolate reductase and drug resistance in Plasmodium falciparum. PLoS One. 2011; 6(5):e19636.
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Treatment of refractory Babesia microti infection with atovaquone-proguanil in an HIV-infected patient: case report. Clin Infect Dis. 2007 Dec 15; 45(12):1588-90.
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Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa. Malar J. 2006 Oct 04; 5:82.
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A public-private partnership for malaria control: lessons from the Malarone Donation Programme. Bull World Health Organ. 2002; 80(10):817-21.
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Atovaquone-proguanil versus mefloquine for malaria prophylaxis in nonimmune travelers: results from a randomized, double-blind study. Clin Infect Dis. 2001 Oct 01; 33(7):1015-21.
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Atovaquone-proguanil versus chloroquine-proguanil for malaria prophylaxis in non-immune travellers: a randomised, double-blind study. Malarone International Study Team. Lancet. 2000 Dec 02; 356(9245):1888-94.