Receptor, Serotonin, 5-HT2C
"Receptor, Serotonin, 5-HT2C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serotonin receptor subtype found primarily in the CENTRAL NERVOUS SYSTEM and the CHOROID PLEXUS. This receptor subtype is believed to mediate the anorectic action of SEROTONIN, while selective antagonists of the 5-HT2C receptor appear to induce ANXIETY. Several isoforms of this receptor subtype exist, due to adenine deaminase editing of the receptor mRNA.
MeSH Number(s)
D12.776.543.750.070.800.200.575
D12.776.543.750.100.800.200.200
D12.776.543.750.720.300.800.200.200
Concept/Terms
Receptor, Serotonin, 5-HT2C- Receptor, Serotonin, 5-HT2C
- 5-HT2C Receptor
- 5 HT2C Receptor
- Receptor, 5-HT2C
- 5-Hydroxytryptamine Type 2C Receptor
- 5 Hydroxytryptamine Type 2C Receptor
- Receptor, 5-Hydroxytryptamine Type 2C
- Receptor, 5 Hydroxytryptamine Type 2C
- Serotonin 2C Receptor
- 2C Receptor, Serotonin
- Receptor, Serotonin 2C
- 5-HT(2C) Receptor
- 5-Hydroxytryptamine Type 2C Receptors
- 5 Hydroxytryptamine Type 2C Receptors
Below are MeSH descriptors whose meaning is more general than "Receptor, Serotonin, 5-HT2C".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Biogenic Amine [D12.776.543.750.070]
- Receptors, Serotonin [D12.776.543.750.070.800]
- Receptors, Serotonin, 5-HT2 [D12.776.543.750.070.800.200]
- Receptor, Serotonin, 5-HT2C [D12.776.543.750.070.800.200.575]
- Receptors, G-Protein-Coupled [D12.776.543.750.100]
- Receptors, Serotonin [D12.776.543.750.100.800]
- Receptors, Serotonin, 5-HT2 [D12.776.543.750.100.800.200]
- Receptor, Serotonin, 5-HT2C [D12.776.543.750.100.800.200.200]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Biogenic Amine [D12.776.543.750.720.300]
- Receptors, Serotonin [D12.776.543.750.720.300.800]
- Receptors, Serotonin, 5-HT2 [D12.776.543.750.720.300.800.200]
- Receptor, Serotonin, 5-HT2C [D12.776.543.750.720.300.800.200.200]
Below are MeSH descriptors whose meaning is more specific than "Receptor, Serotonin, 5-HT2C".
This graph shows the total number of publications written about "Receptor, Serotonin, 5-HT2C" by people in Harvard Catalyst Profiles by year, and whether "Receptor, Serotonin, 5-HT2C" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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2000 | 0 | 1 | 1 |
2001 | 0 | 2 | 2 |
2002 | 0 | 2 | 2 |
2005 | 0 | 2 | 2 |
2006 | 2 | 1 | 3 |
2007 | 1 | 0 | 1 |
2008 | 1 | 0 | 1 |
2010 | 1 | 3 | 4 |
2011 | 1 | 0 | 1 |
2012 | 2 | 1 | 3 |
2015 | 2 | 1 | 3 |
2016 | 1 | 2 | 3 |
2017 | 1 | 2 | 3 |
2018 | 0 | 2 | 2 |
2022 | 0 | 2 | 2 |
Below are the most recent publications written about "Receptor, Serotonin, 5-HT2C" by people in Profiles.
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Circulating total and intact GDF-15 levels are not altered in response to weight loss induced by liraglutide or lorcaserin treatment in humans with obesity. Metabolism. 2022 08; 133:155237.
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A new class of 5-HT2A /5-HT2C receptor inverse agonists: Synthesis, molecular modeling, in vitro and in vivo pharmacology of novel 2-aminotetralins. Br J Pharmacol. 2022 06; 179(11):2610-2630.
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Reassessment of the involvement of Snord115 in the serotonin 2c receptor pathway in a genetically relevant mouse model. Elife. 2020 10 05; 9.
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Identification of fluorinated (R)-(-)-aporphine derivatives as potent and selective ligands at serotonin 5-HT2C receptor. Bioorg Med Chem Lett. 2019 01 15; 29(2):230-233.
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Lorcaserin decreases the reinforcing effects of heroin, but not food, in rhesus monkeys. Eur J Pharmacol. 2018 Dec 05; 840:28-32.
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Specific subpopulations of hypothalamic leptin receptor-expressing neurons mediate the effects of early developmental leptin receptor deletion on energy balance. Mol Metab. 2018 08; 14:130-138.
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Effects of lorcaserin (Belviq®) on nicotine- and food-maintained responding in non-human primates. Drug Alcohol Depend. 2017 12 01; 181:94-101.
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Central amygdala circuits modulate food consumption through a positive-valence mechanism. Nat Neurosci. 2017 Oct; 20(10):1384-1394.
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Discovery of N-Substituted (2-Phenylcyclopropyl)methylamines as Functionally Selective Serotonin 2C Receptor Agonists for Potential Use as Antipsychotic Medications. J Med Chem. 2017 07 27; 60(14):6273-6288.
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Effects of lorcaserin on fat and lean mass loss in obese and overweight patients without and with type 2 diabetes mellitus: the BLOSSOM and BLOOM-DM studies. Diabetes Obes Metab. 2016 09; 18(9):945-8.