HMGN1 Protein

"HMGN1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An evolutionarily-conserved 10-kDa nuclear protein that binds NUCLEOSOMES and may be involved in the process of CHROMATIN unfolding.

Descriptor ID

D024241

MeSH Number(s)

D12.776.660.235.400.400.200

D12.776.664.235.400.400.200

Concept/Terms

HMGN1 Protein

Below are MeSH descriptors whose meaning is more general than "HMGN1 Protein".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Nuclear Proteins [D12.776.660]
Chromosomal Proteins, Non-Histone [D12.776.660.235]
High Mobility Group Proteins [D12.776.660.235.400]
HMGN Proteins [D12.776.660.235.400.400]
HMGN1 Protein [D12.776.660.235.400.400.200]
Nucleoproteins [D12.776.664]
Chromosomal Proteins, Non-Histone [D12.776.664.235]
High Mobility Group Proteins [D12.776.664.235.400]
HMGN Proteins [D12.776.664.235.400.400]
HMGN1 Protein [D12.776.664.235.400.400.200]

Below are MeSH descriptors whose meaning is related to "HMGN1 Protein".

Below are MeSH descriptors whose meaning is more specific than "HMGN1 Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "HMGN1 Protein" by people in Harvard Catalyst Profiles by year, and whether "HMGN1 Protein" was a major or minor topic of these publication.

Bar chart showing 7 publications over 6 distinct years, with a maximum of 2 publications in 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2014	1	0	1
2015	1	0	1
2018	1	0	1
2019	1	0	1
2020	0	1	1
2021	2	0	2

Below are the most recent publications written about "HMGN1 Protein" by people in Profiles.

A TNFR2 antibody by countering immunosuppression cooperates with HMGN1 and R848 immune stimulants to inhibit murine colon cancer. Int Immunopharmacol. 2021 Dec; 101(Pt A):108345.

View in: PubMed
Combining an Alarmin HMGN1 Peptide with PD-L1 Blockade Results in Robust Antitumor Effects with a Concomitant Increase of Stem-Like/Progenitor Exhausted CD8+ T Cells. Cancer Immunol Res. 2021 10; 9(10):1214-1228.

View in: PubMed
Chromatin accessibility promotes hematopoietic and leukemia stem cell activity. Nat Commun. 2020 03 16; 11(1):1406.

View in: PubMed
Combined treatment with HMGN1 and anti-CD4 depleting antibody reverses T cell exhaustion and exerts robust anti-tumor effects in mice. J Immunother Cancer. 2019 01 29; 7(1):21.

View in: PubMed
Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression. Cell Rep. 2018 11 13; 25(7):1898-1911.e5.

View in: PubMed
Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949). Mol Psychiatry. 2015 Feb; 20(2):183-92.

View in: PubMed
Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation. Nat Genet. 2014 Jun; 46(6):618-23.

View in: PubMed
HMGN proteins act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility. Mol Cell. 2009 Jun 12; 34(5):620-6.

View in: PubMed
Increased genomic instability and altered chromosomal protein phosphorylation timing in HRAS-transformed mouse fibroblasts. Genes Chromosomes Cancer. 2009 May; 48(5):397-409.

View in: PubMed
Phosphorylation of human high mobility group N1 protein by protein kinase CK2. Biochem Biophys Res Commun. 2006 Jul 14; 345(4):1497-503.

View in: PubMed

Related Networks

People

Explore

Similar Concepts

Top Journals

Nat Genet
Mol Psychiatry
Mol Cell
J Immunother Cancer
Int Immunopharmacol
Genes Chromosomes Cancer
Cell Rep
Cancer Immunol Res
Biochem Biophys Res Commun
Nat Commun