Nucleic Acid Heteroduplexes
"Nucleic Acid Heteroduplexes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Double-stranded nucleic acid molecules (DNA-DNA or DNA-RNA) which contain regions of nucleotide mismatches (non-complementary). In vivo, these heteroduplexes can result from mutation or genetic recombination; in vitro, they are formed by nucleic acid hybridization. Electron microscopic analysis of the resulting heteroduplexes facilitates the mapping of regions of base sequence homology of nucleic acids.
Below are MeSH descriptors whose meaning is more general than "Nucleic Acid Heteroduplexes".
Below are MeSH descriptors whose meaning is more specific than "Nucleic Acid Heteroduplexes".
This graph shows the total number of publications written about "Nucleic Acid Heteroduplexes" by people in Harvard Catalyst Profiles by year, and whether "Nucleic Acid Heteroduplexes" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1995 | 0 | 1 | 1 |
| 1996 | 3 | 0 | 3 |
| 1997 | 2 | 1 | 3 |
| 1998 | 0 | 3 | 3 |
| 1999 | 2 | 1 | 3 |
| 2000 | 1 | 4 | 5 |
| 2001 | 1 | 0 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 1 | 1 | 2 |
| 2005 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 2 | 0 | 2 |
Below are the most recent publications written about "Nucleic Acid Heteroduplexes" by people in Profiles.
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Znc2 module of RAG1 contributes towards structure-specific nuclease activity of RAGs. Biochem J. 2020 09 30; 477(18):3567-3582.
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Highly efficient gene silencing in mouse brain by overhanging-duplex oligonucleotides via intraventricular route. FEBS Lett. 2020 05; 594(9):1413-1423.
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Highly efficient silencing of microRNA by heteroduplex oligonucleotides. Nucleic Acids Res. 2019 08 22; 47(14):7321-7332.
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A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases. Nat Commun. 2018 10 10; 9(1):4201.
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Regulation of hetDNA Length during Mitotic Double-Strand Break Repair in Yeast. Mol Cell. 2017 Aug 17; 67(4):539-549.e4.
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The poor homology stringency in the heteroduplex allows strand exchange to incorporate desirable mismatches without sacrificing recognition in vivo. Nucleic Acids Res. 2015 Jul 27; 43(13):6473-85.
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Extensive recombination due to heteroduplexes generates large amounts of artificial gene fragments during PCR. PLoS One. 2014; 9(9):e106658.
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Substrate recognition and specificity of double-stranded RNA binding proteins. Biochemistry. 2014 Jun 03; 53(21):3457-66.
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Structural insights into the effects of 2'-5' linkages on the RNA duplex. Proc Natl Acad Sci U S A. 2014 Feb 25; 111(8):3050-5.
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Removal of N-6-methyladenine by the nucleotide excision repair pathway triggers the repair of mismatches in yeast gap-repair intermediates. DNA Repair (Amst). 2013 Dec; 12(12):1053-61.