Post-Synaptic Density

"Post-Synaptic Density" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Cytoskeleton specialization at the cytoplasmic side of postsynaptic membrane in SYNAPSES. It is involved in neuronal signaling and NEURONAL PLASTICITY and comprised of GLUTAMATE RECEPTORS; scaffolding molecules (e.g., PSD95, PSD93), and other proteins (e.g., CaCMKII).

Descriptor ID

D057907

MeSH Number(s)

A08.850.800.500

A11.284.149.165.420.780.800.500

Concept/Terms

Post-Synaptic Density

Below are MeSH descriptors whose meaning is more general than "Post-Synaptic Density".

Anatomy [A]
Nervous System [A08]
Synapses [A08.850]
Synaptic Membranes [A08.850.800]
Post-Synaptic Density [A08.850.800.500]
Cells [A11]
Cellular Structures [A11.284]
Cell Membrane [A11.284.149]
Cell Membrane Structures [A11.284.149.165]
Intercellular Junctions [A11.284.149.165.420]
Synapses [A11.284.149.165.420.780]
Synaptic Membranes [A11.284.149.165.420.780.800]
Post-Synaptic Density [A11.284.149.165.420.780.800.500]

Below are MeSH descriptors whose meaning is related to "Post-Synaptic Density".

Below are MeSH descriptors whose meaning is more specific than "Post-Synaptic Density".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Post-Synaptic Density" by people in Harvard Catalyst Profiles by year, and whether "Post-Synaptic Density" was a major or minor topic of these publication.

Bar chart showing 10 publications over 5 distinct years, with a maximum of 3 publications in 2011 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2011	2	1	3
2012	0	1	1
2014	0	1	1
2016	0	2	2
2017	2	1	3

Below are the most recent publications written about "Post-Synaptic Density" by people in Profiles.

Stem cell-derived neurons from autistic individuals with SHANK3 mutation show morphogenetic abnormalities during early development. Mol Psychiatry. 2018 03; 23(3):735-746.

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Proteasome-independent polyubiquitin linkage regulates synapse scaffolding, efficacy, and plasticity. Proc Natl Acad Sci U S A. 2017 10 10; 114(41):E8760-E8769.

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Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Nat Neurosci. 2017 Aug; 20(8):1150-1161.

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Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes. Neuron. 2017 May 03; 94(3):569-580.e5.

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Optogenetic Control of Synaptic Composition and Function. Neuron. 2017 Feb 08; 93(3):646-660.e5.

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Nanoscale Molecular Reorganization of the Inhibitory Postsynaptic Density Is a Determinant of GABAergic Synaptic Potentiation. J Neurosci. 2017 02 15; 37(7):1747-1756.

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Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking. Neuron. 2016 Aug 17; 91(4):777-791.

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Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice. Mol Psychiatry. 2017 05; 22(5):689-702.

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Development of a highly automated and multiplexed targeted proteome pipeline and assay for 112 rat brain synaptic proteins. Proteomics. 2015 Apr; 15(7):1202-14.

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Src kinase as a mediator of convergent molecular abnormalities leading to NMDAR hypoactivity in schizophrenia. Mol Psychiatry. 2015 Sep; 20(9):1091-100.

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