Phospholipases A2, Secretory
"Phospholipases A2, Secretory" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subcategory of phospholipases A2 that are secreted from cells. They are 14 kDa proteins containing multiple disulfide-bonds and access their substrate via an interfacial binding site that interacts with phospholipid membranes. In addition specific PHOSPHOLIPASE A2 RECEPTORS can bind to and internalize the enzymes.
MeSH Number(s)
D08.811.277.352.100.680.750.937.750
Concept/Terms
Phospholipases A2, Secretory- Phospholipases A2, Secretory
- Secretory Phospholipases A2
- Secreted Phospholipases A2
- sPLA2s
- sPLA(2)
- SPLA2 Phospholipases
- Phospholipases, SPLA2
- Phospholipases A2, Secreted
- Secretory Phospholipase A2
- Phospholipase A2, Secretory
Below are MeSH descriptors whose meaning is more general than "Phospholipases A2, Secretory".
Below are MeSH descriptors whose meaning is more specific than "Phospholipases A2, Secretory".
This graph shows the total number of publications written about "Phospholipases A2, Secretory" by people in Harvard Catalyst Profiles by year, and whether "Phospholipases A2, Secretory" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 2 | 1 | 3 |
| 2011 | 1 | 0 | 1 |
| 2012 | 3 | 1 | 4 |
| 2013 | 3 | 0 | 3 |
| 2015 | 1 | 1 | 2 |
| 2019 | 1 | 0 | 1 |
Below are the most recent publications written about "Phospholipases A2, Secretory" by people in Profiles.
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Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS. Cell. 2019 12 12; 179(7):1483-1498.e22.
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Secreted phospholipase A2 of Clonorchis sinensis activates hepatic stellate cells through a pathway involving JNK signalling. Parasit Vectors. 2017 Mar 16; 10(1):147.
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Protective role for club cell secretory protein-16 (CC16) in the development of COPD. Eur Respir J. 2015 Jun; 45(6):1544-56.
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Detection and quantification of microparticles from different cellular lineages using flow cytometry. Evaluation of the impact of secreted phospholipase A2 on microparticle assessment. PLoS One. 2015; 10(1):e0116812.
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Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial. JAMA. 2014 Jan 15; 311(3):252-62.
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Reply: limits of Mendelian randomization analyses in selection of secretory phospholipase A2-IIA as a valid therapeutic target for prevention of cardiovascular disease. J Am Coll Cardiol. 2014 Mar 11; 63(9):943.
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Lactadherin inhibits secretory phospholipase A2 activity on pre-apoptotic leukemia cells. PLoS One. 2013; 8(10):e77143.
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Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study. J Am Coll Cardiol. 2013 Nov 19; 62(21):1966-1976.
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In vivo platelet activation and platelet hyperreactivity in abacavir-treated HIV-infected patients. Thromb Haemost. 2013 Aug; 110(2):349-57.
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Trafficking of endogenous smooth muscle cell cholesterol: a role for serum amyloid A and interleukin-1ß. Arterioscler Thromb Vasc Biol. 2012 Nov; 32(11):2741-50.