Intermediate-Conductance Calcium-Activated Potassium Channels
"Intermediate-Conductance Calcium-Activated Potassium Channels" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A major class of calcium-activated potassium channels that were originally discovered in ERYTHROCYTES. They are found primarily in non-excitable CELLS and set up electrical gradients for PASSIVE ION TRANSPORT.
MeSH Number(s)
D12.776.157.530.400.600.150.249
D12.776.543.550.425.750.150.249
D12.776.543.585.400.750.150.249
Concept/Terms
Intermediate-Conductance Calcium-Activated Potassium Channels- Intermediate-Conductance Calcium-Activated Potassium Channels
- Intermediate Conductance Calcium Activated Potassium Channels
- IK Potassium Channels
- Potassium Channels, IK
- Potassium Channels, Intermediate-Conductance Calcium-Activated
- Potassium Channels, Intermediate Conductance Calcium Activated
Below are MeSH descriptors whose meaning is more general than "Intermediate-Conductance Calcium-Activated Potassium Channels".
Below are MeSH descriptors whose meaning is more specific than "Intermediate-Conductance Calcium-Activated Potassium Channels".
This graph shows the total number of publications written about "Intermediate-Conductance Calcium-Activated Potassium Channels" by people in Harvard Catalyst Profiles by year, and whether "Intermediate-Conductance Calcium-Activated Potassium Channels" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1998 | 0 | 1 | 1 |
2004 | 0 | 1 | 1 |
2005 | 0 | 1 | 1 |
2006 | 0 | 1 | 1 |
2008 | 1 | 1 | 2 |
2009 | 0 | 1 | 1 |
2010 | 0 | 1 | 1 |
2012 | 1 | 2 | 3 |
2013 | 1 | 3 | 4 |
2015 | 1 | 1 | 2 |
2017 | 2 | 0 | 2 |
2018 | 1 | 0 | 1 |
2019 | 1 | 1 | 2 |
2021 | 0 | 1 | 1 |
2022 | 0 | 2 | 2 |
Below are the most recent publications written about "Intermediate-Conductance Calcium-Activated Potassium Channels" by people in Profiles.
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Can KCa3.1 channel activators serve as novel inhibitors of platelet aggregation? J Thromb Haemost. 2022 11; 20(11):2488-2490.
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The erythroid K-Cl cotransport inhibitor [(dihydroindenyl)oxy]acetic acid blocks erythroid Ca2+-activated K+ channel KCNN4. Am J Physiol Cell Physiol. 2022 09 01; 323(3):C694-C705.
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Haemoglobin response to senicapoc in patients with sickle cell disease: a re-analysis of the Phase III trial. Br J Haematol. 2021 03; 192(5):e129-e132.
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Combined genetic disruption of K-Cl cotransporters and Gardos channel KCNN4 rescues erythrocyte dehydration in the SAD mouse model of sickle cell disease. Blood Cells Mol Dis. 2019 11; 79:102346.
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Erythrocyte ion content and dehydration modulate maximal Gardos channel activity in KCNN4 V282M/+ hereditary xerocytosis red cells. Am J Physiol Cell Physiol. 2019 08 01; 317(2):C287-C302.
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Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection. Cell. 2018 04 05; 173(2):443-455.e12.
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Sickle cell dehydration: Pathophysiology and therapeutic applications. Clin Hemorheol Microcirc. 2018; 68(2-3):187-204.
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Ca2+-Dependent Regulation of NFATc1 via KCa3.1 in Inflammatory Osteoclastogenesis. J Immunol. 2018 01 15; 200(2):749-757.
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Erythrocytes from hereditary xerocytosis patients heterozygous for KCNN4 V282M exhibit increased spontaneous Gardos channel-like activity inhibited by senicapoc. Am J Hematol. 2017 06; 92(6):E108-E110.
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The Clinically Tested Gardos Channel Inhibitor Senicapoc Exhibits Antimalarial Activity. Antimicrob Agents Chemother. 2016 01; 60(1):613-6.