2',5'-Oligoadenylate Synthetase
"2',5'-Oligoadenylate Synthetase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (RNase L) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions. EC 2.7.7.-.
Concept/Terms
2',5'-Oligoadenylate Synthetase- 2',5'-Oligoadenylate Synthetase
- 2',5' Oligoadenylate Synthetase
- Synthetase, 2',5'-Oligoadenylate
- 2,5 Oligoadenylate Polymerase
- Oligoadenylate Polymerase, 2,5
- Polymerase, 2,5 Oligoadenylate
- 2',5'-Oligoadenylate Polymerase
- 2',5' Oligoadenylate Polymerase
- Polymerase, 2',5'-Oligoadenylate
- (2'-5')An Polymerase
- ATP-(2'-5')oligo(A)adenylyltransferase
- 2',5'-Oligo(A) Synthetase
- 2',5'-Oligo(A) Polymerase
- 2,5 Oligoadenylate Synthetase
- Oligoadenylate Synthetase, 2,5
- Synthetase, 2,5 Oligoadenylate
- 2-5A Synthetase
- 2 5A Synthetase
Below are MeSH descriptors whose meaning is more general than "2',5'-Oligoadenylate Synthetase".
Below are MeSH descriptors whose meaning is more specific than "2',5'-Oligoadenylate Synthetase".
This graph shows the total number of publications written about "2',5'-Oligoadenylate Synthetase" by people in Harvard Catalyst Profiles by year, and whether "2',5'-Oligoadenylate Synthetase" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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2004 | 1 | 1 | 2 |
2005 | 1 | 0 | 1 |
2010 | 1 | 0 | 1 |
2013 | 0 | 3 | 3 |
2017 | 1 | 1 | 2 |
2019 | 2 | 1 | 3 |
2021 | 1 | 0 | 1 |
2022 | 1 | 1 | 2 |
Below are the most recent publications written about "2',5'-Oligoadenylate Synthetase" by people in Profiles.
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Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries. Nat Genet. 2022 08; 54(8):1103-1116.
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Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19. Nat Genet. 2022 02; 54(2):125-127.
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A prenylated dsRNA sensor protects against severe COVID-19. Science. 2021 Oct 29; 374(6567):eabj3624.
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Genetic mechanisms of critical illness in COVID-19. Nature. 2021 03; 591(7848):92-98.
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Alternative splicing coupled with transcript degradation modulates OAS1g antiviral activity. RNA. 2020 02; 26(2):126-136.
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Recurrent Loss-of-Function Mutations Reveal Costs to OAS1 Antiviral Activity in Primates. Cell Host Microbe. 2019 02 13; 25(2):336-343.e4.
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Double-Stranded RNA Sensors and Modulators in Innate Immunity. Annu Rev Immunol. 2019 04 26; 37:349-375.
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Identified OAS3 gene variants associated with coexistence of HBsAg and anti-HBs in chronic HBV infection. J Viral Hepat. 2018 08; 25(8):904-910.
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Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons. PLoS Genet. 2017 Jun; 13(6):e1006820.
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Short-Course Toll-Like Receptor 9 Agonist Treatment Impacts Innate Immunity and Plasma Viremia in Individuals With Human Immunodeficiency Virus Infection. Clin Infect Dis. 2017 Jun 15; 64(12):1686-1695.