"Tubulin Modulators" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES.
Concept/Terms
Tubulin Modulators- Tubulin Modulators
- Modulators, Tubulin
- Microtubule Modulators
- Modulators, Microtubule
Tubulin Promoters- Tubulin Promoters
- Promoters, Tubulin
- Tubulin Polymerization Promoters
- Polymerization Promoters, Tubulin
- Promoters, Tubulin Polymerization
Tubulin Inhibitors- Tubulin Inhibitors
- Inhibitors, Tubulin
- Tubulin Polymerization Inhibitors
- Inhibitors, Tubulin Polymerization
- Polymerization Inhibitors, Tubulin
Below are MeSH descriptors whose meaning is more general than "Tubulin Modulators".
Below are MeSH descriptors whose meaning is more specific than "Tubulin Modulators".
This graph shows the total number of publications written about "Tubulin Modulators" by people in Harvard Catalyst Profiles by year, and whether "Tubulin Modulators" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 2 | 1 | 3 |
| 2008 | 3 | 5 | 8 |
| 2009 | 2 | 4 | 6 |
| 2010 | 4 | 0 | 4 |
| 2011 | 2 | 2 | 4 |
| 2012 | 6 | 4 | 10 |
| 2013 | 3 | 2 | 5 |
| 2014 | 3 | 2 | 5 |
| 2015 | 0 | 2 | 2 |
| 2016 | 1 | 3 | 4 |
| 2017 | 5 | 4 | 9 |
| 2018 | 4 | 2 | 6 |
| 2019 | 5 | 2 | 7 |
| 2020 | 3 | 4 | 7 |
| 2021 | 1 | 2 | 3 |
| 2022 | 0 | 1 | 1 |
Below are the most recent publications written about "Tubulin Modulators" by people in Profiles.
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Evolution of Potential Antimitotic Stapled Peptides from Multiple Helical Peptide Stretches of the Tubulin Heterodimer Interface: Helix-Mimicking Stapled Peptide Tubulin Inhibitors. J Med Chem. 2022 10 27; 65(20):13866-13878.
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A new class of cytotoxic agents targets tubulin and disrupts microtubule dynamics. Bioorg Chem. 2021 11; 116:105297.
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Potential colchicine binding site inhibitors unraveled by virtual screening, molecular dynamics and MM/PBSA. Comput Biol Med. 2021 10; 137:104817.
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Cinnamide derived pyrimidine-benzimidazole hybrids as tubulin inhibitors: Synthesis, in silico and cell growth inhibition studies. Bioorg Chem. 2021 05; 110:104765.
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Cost-Effectiveness of Neoadjuvant-Adjuvant Treatment Strategies for Women With ERBB2 (HER2)-Positive Breast Cancer. JAMA Netw Open. 2020 11 02; 3(11):e2027074.
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Identification of novel aß-tubulin modulators with antiproliferative activity directed to cancer therapy using ligand and structure-based virtual screening. Int J Biol Macromol. 2020 Dec 15; 165(Pt B):3040-3050.
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Prediction Model for Freedom from TLR from a Multi-study Analysis of Long-Term Results with the Zilver PTX Drug-Eluting Peripheral Stent. Cardiovasc Intervent Radiol. 2021 Feb; 44(2):196-206.
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A novel orally active microtubule destabilizing agent S-40 targets the colchicine-binding site and shows potent antitumor activity. Cancer Lett. 2020 12 28; 495:22-32.
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Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer's disease model. Sci Rep. 2020 09 08; 10(1):14776.
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Update on paclitaxel for femoral-popliteal occlusive disease in the 15 months following a summary level meta-analysis demonstrated increased risk of late mortality and dose response to paclitaxel. J Vasc Surg. 2021 01; 73(1):311-322.