Thyroid Hormone Resistance Syndrome
"Thyroid Hormone Resistance Syndrome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An inherited autosomal recessive trait, characterized by peripheral resistance to THYROID HORMONES and the resulting elevation in serum levels of THYROXINE and TRIIODOTHYRONINE. This syndrome is caused by mutations of gene THRB encoding the THYROID HORMONE RECEPTORS BETA in target cells. HYPOTHYROIDISM in these patients is partly overcome by the increased thyroid hormone levels.
Concept/Terms
Thyroid Hormone Resistance Syndrome- Thyroid Hormone Resistance Syndrome
- Generalized Resistance to Thyroid Hormone
- Refetoff-DeWind-DeGroot Syndrome
- Refetoff DeWind DeGroot Syndrome
- Syndrome, Refetoff-DeWind-DeGroot
- Thyroid Hormone Resistance
- Hormone Resistance, Thyroid
- Resistance, Thyroid Hormone
- Generalized Thyroid Hormone Resistance
- Refetoff Syndrome
- Syndrome, Refetoff
Below are MeSH descriptors whose meaning is more general than "Thyroid Hormone Resistance Syndrome".
Below are MeSH descriptors whose meaning is more specific than "Thyroid Hormone Resistance Syndrome".
This graph shows the total number of publications written about "Thyroid Hormone Resistance Syndrome" by people in Harvard Catalyst Profiles by year, and whether "Thyroid Hormone Resistance Syndrome" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 2 | 0 | 2 |
| 1995 | 1 | 1 | 2 |
| 1999 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2001 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
Below are the most recent publications written about "Thyroid Hormone Resistance Syndrome" by people in Profiles.
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Resistance to Thyroid Hormone Beta: A Focused Review. Front Endocrinol (Lausanne). 2021; 12:656551.
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Human Genetics of Thyroid Hormone Receptor Beta: Resistance to Thyroid Hormone Beta (RTHß). Methods Mol Biol. 2018; 1801:225-240.
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Prenatal Diagnosis of Resistance to Thyroid Hormone and Its Clinical Implications. J Clin Endocrinol Metab. 2017 10 01; 102(10):3775-3782.
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Resistance to thyroid hormone a, revelation of basic study to clinical consequences. J Pediatr Endocrinol Metab. 2016 May 01; 29(5):511-22.
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Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors. Mol Cell Biol. 2014 May; 34(9):1564-75.
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RTHa, a newly recognized phenotype of the resistance to thyroid hormone (RTH) syndrome in patients with THRA gene mutations. J Clin Endocrinol Metab. 2013 Jul; 98(7):2684-6.
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Is there a role for inherited TRß mutation in human carcinogenesis? [corrected]. Arq Bras Endocrinol Metabol. 2012 Feb; 56(1):67-71.
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Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1). Proc Natl Acad Sci U S A. 2011 Oct 18; 108(42):17462-7.
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Dichotomous responses to thyroid hormone treatment in a patient with primary hypothyroidism and thyroid hormone resistance. Thyroid. 2011 May; 21(5):559-61.
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Alopecia: association with resistance to thyroid hormones. J Pediatr Endocrinol Metab. 2009 Nov; 22(11):1075-81.