Eukaryotic Initiation Factor-2

"Eukaryotic Initiation Factor-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Eukaryotic initiation factor of protein synthesis. In higher eukaryotes the factor consists of three subunits: alpha, beta, and gamma. As initiation proceeds, eIF-2 forms a ternary complex with Met-tRNAi and GTP.

Descriptor ID

D015852

MeSH Number(s)

D12.776.835.725.868.249

Concept/Terms

Eukaryotic Initiation Factor-2

Eukaryotic Initiation Factor-2, gamma Subunit

Eukaryotic Initiation Factor-2, alpha Subunit

Eukaryotic Initiation Factor-2, beta Subunit

Below are MeSH descriptors whose meaning is more general than "Eukaryotic Initiation Factor-2".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Ribosomal Proteins [D12.776.835]
Peptide Initiation Factors [D12.776.835.725]
Eukaryotic Initiation Factors [D12.776.835.725.868]
Eukaryotic Initiation Factor-2 [D12.776.835.725.868.249]

Below are MeSH descriptors whose meaning is related to "Eukaryotic Initiation Factor-2".

Below are MeSH descriptors whose meaning is more specific than "Eukaryotic Initiation Factor-2".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Eukaryotic Initiation Factor-2" by people in Harvard Catalyst Profiles by year, and whether "Eukaryotic Initiation Factor-2" was a major or minor topic of these publication.

Bar chart showing 131 publications over 26 distinct years, with a maximum of 11 publications in 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
1997	0	1	1
1998	1	2	3
1999	1	0	1
2001	0	3	3
2002	3	3	6
2004	2	3	5
2005	5	5	10
2006	2	5	7
2007	0	4	4
2008	1	2	3
2009	3	5	8
2010	1	3	4
2011	0	6	6
2012	3	4	7
2013	2	4	6
2014	1	6	7
2015	4	4	8
2016	3	8	11
2017	4	2	6
2018	2	4	6
2019	5	2	7
2020	1	3	4
2021	0	5	5
2022	1	0	1
2023	1	0	1

Below are the most recent publications written about "Eukaryotic Initiation Factor-2" by people in Profiles.

eIF3d controls the persistent integrated stress response. Mol Cell. 2023 09 21; 83(18):3303-3313.e6.

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Role of symmetry in 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as inhibitors of translation initiation. Bioorg Med Chem Lett. 2023 01 15; 80:129119.

View in: PubMed
Translation inhibitory elements from Hoxa3 and Hoxa11 mRNAs use uORFs for translation inhibition. Elife. 2021 06 02; 10.

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SARS-CoV-2 infection induces beta cell transdifferentiation. Cell Metab. 2021 08 03; 33(8):1577-1591.e7.

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Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation. Nat Commun. 2021 03 15; 12(1):1678.

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Bisphenol A promotes stress granule assembly and modulates the integrated stress response. Biol Open. 2021 01 10; 10(1).

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QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis. Science. 2021 01 01; 371(6524).

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Dystonia 16 (DYT16) mutations in PACT cause dysregulated PKR activation and eIF2a signaling leading to a compromised stress response. Neurobiol Dis. 2020 12; 146:105135.

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Protein Stability Buffers the Cost of Translation Attenuation following eIF2a Phosphorylation. Cell Rep. 2020 09 15; 32(11):108154.

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The unfolded protein response is activated in the olfactory system in Alzheimer's disease. Acta Neuropathol Commun. 2020 07 14; 8(1):109.

View in: PubMed

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