Synaptotagmin II

"Synaptotagmin II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A vesicular transport protein that was originally characterized as an inositol polyphosphate binding protein. Synaptotagmin II helps regulate EXOCYTOSIS of SYNAPTIC VESICLES and appears to serve as a calcium sensor to trigger NEUROTRANSMITTER release. It also acts as a nerve cell receptor for certain BOTULINUM TOXINS.

Descriptor ID

D050861

MeSH Number(s)

D12.776.157.125.825.500

D12.776.543.990.850.500

Concept/Terms

Synaptotagmin II

Below are MeSH descriptors whose meaning is more general than "Synaptotagmin II".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Calcium-Binding Proteins [D12.776.157.125]
Synaptotagmins [D12.776.157.125.825]
Synaptotagmin II [D12.776.157.125.825.500]
Membrane Proteins [D12.776.543]
Vesicular Transport Proteins [D12.776.543.990]
Synaptotagmins [D12.776.543.990.850]
Synaptotagmin II [D12.776.543.990.850.500]

Below are MeSH descriptors whose meaning is related to "Synaptotagmin II".

Below are MeSH descriptors whose meaning is more specific than "Synaptotagmin II".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Synaptotagmin II" by people in Harvard Catalyst Profiles by year, and whether "Synaptotagmin II" was a major or minor topic of these publication.

Bar chart showing 7 publications over 6 distinct years, with a maximum of 2 publications in 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2010	0	1	1
2012	1	0	1
2015	0	1	1
2017	1	0	1
2019	2	0	2
2021	1	0	1

Below are the most recent publications written about "Synaptotagmin II" by people in Profiles.

Knockin mouse models demonstrate differential contributions of synaptotagmin-1 and -2 as receptors for botulinum neurotoxins. PLoS Pathog. 2021 10; 17(10):e1009994.

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Structural maturation of cortical perineuronal nets and their perforating synapses revealed by superresolution imaging. Proc Natl Acad Sci U S A. 2019 04 02; 116(14):7071-7076.

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Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models. Sci Adv. 2019 01; 5(1):eaau7196.

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Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors. Nat Commun. 2017 07 03; 8(1):53.

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Electrophysiologic features of SYT2 mutations causing a treatable neuromuscular syndrome. Neurology. 2015 Dec 01; 85(22):1964-71.

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Synaptotagmins interact with APP and promote Aß generation. Mol Neurodegener. 2015 Jul 23; 10:31.

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Synaptotagmin 2 mutations cause an autosomal-dominant form of lambert-eaton myasthenic syndrome and nonprogressive motor neuropathy. Am J Hum Genet. 2014 Sep 04; 95(3):332-9.

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Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins. J Cell Sci. 2012 Jul 01; 125(Pt 13):3233-42.

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Synaptotagmin-mediated vesicle fusion regulates cell migration. Nat Immunol. 2010 Jun; 11(6):495-502.

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