Thiostrepton

"Thiostrepton" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

One of the CYCLIC PEPTIDES from Streptomyces that is active against gram-positive bacteria. In veterinary medicine, it has been used in mastitis caused by gram-negative organisms and in dermatologic disorders.

Descriptor ID

D013883

MeSH Number(s)

D04.345.566.825

D12.644.641.825

Concept/Terms

Below are MeSH descriptors whose meaning is more general than "Thiostrepton".

Chemicals and Drugs [D]
Polycyclic Compounds [D04]
Macrocyclic Compounds [D04.345]
Peptides, Cyclic [D04.345.566]
Thiostrepton [D04.345.566.825]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Peptides, Cyclic [D12.644.641]
Thiostrepton [D12.644.641.825]

Below are MeSH descriptors whose meaning is related to "Thiostrepton".

Below are MeSH descriptors whose meaning is more specific than "Thiostrepton".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Thiostrepton" by people in Harvard Catalyst Profiles by year, and whether "Thiostrepton" was a major or minor topic of these publication.

Bar chart showing 5 publications over 5 distinct years, with a maximum of 1 publications in 2002 and 2006 and 2011 and 2015 and 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2006	0	1	1
2011	1	0	1
2015	1	0	1
2020	1	0	1

Below are the most recent publications written about "Thiostrepton" by people in Profiles.

Interception of the Bycroft-Gowland Intermediate in the Enzymatic Macrocyclization of Thiopeptides. J Am Chem Soc. 2020 07 29; 142(30):13170-13179.

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Functional roles in S-adenosyl-L-methionine binding and catalysis for active site residues of the thiostrepton resistance methyltransferase. FEBS Lett. 2015 Oct 24; 589(21):3263-70.

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Thiostrepton interacts covalently with Rpt subunits of the 19S proteasome and proteasome substrates. J Cell Mol Med. 2015 Sep; 19(9):2181-92.

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Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma. PLoS One. 2015; 10(5):e0127310.

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Binding induced RNA conformational changes control substrate recognition and catalysis by the thiostrepton resistance methyltransferase (Tsr). J Biol Chem. 2014 Sep 19; 289(38):26189-26200.

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Combination treatment with bortezomib and thiostrepton is effective against tumor formation in mouse models of DEN/PB-induced liver carcinogenesis. Cell Cycle. 2012 Sep 15; 11(18):3370-2.

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Peroxiredoxin 3 is a redox-dependent target of thiostrepton in malignant mesothelioma cells. PLoS One. 2012; 7(6):e39404.

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Thiostrepton is an inducer of oxidative and proteotoxic stress that impairs viability of human melanoma cells but not primary melanocytes. Biochem Pharmacol. 2012 May 01; 83(9):1229-40.

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Thiostrepton and derivatives exhibit antimalarial and gametocytocidal activity by dually targeting parasite proteasome and apicoplast. Antimicrob Agents Chemother. 2011 Apr; 55(4):1338-48.

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Thiazole antibiotics against breast cancer. Cell Cycle. 2010 Mar 15; 9(6):1214-7.

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