Replication Protein C

"Replication Protein C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A DNA-binding protein that consists of 5 polypeptides and plays an essential role in DNA REPLICATION in eukaryotes. It binds DNA PRIMER-template junctions and recruits PROLIFERATING CELL NUCLEAR ANTIGEN and DNA POLYMERASES to the site of DNA synthesis.

Descriptor ID

D051818

MeSH Number(s)

D12.776.260.702

Concept/Terms

Replication Protein C

Replication Protein C, Subunit 4

Replication Protein C, Subunit 2

Replication Protein C, Subunit 1

Replication Protein C, Subunit 3

Replication Protein C, Subunit 5

Below are MeSH descriptors whose meaning is more general than "Replication Protein C".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Replication Protein C [D12.776.260.702]

Below are MeSH descriptors whose meaning is related to "Replication Protein C".

Below are MeSH descriptors whose meaning is more specific than "Replication Protein C".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Replication Protein C" by people in Harvard Catalyst Profiles by year, and whether "Replication Protein C" was a major or minor topic of these publication.

Bar chart showing 16 publications over 12 distinct years, with a maximum of 3 publications in 2001

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
1996	0	1	1
1997	0	1	1
1998	0	1	1
1999	0	1	1
2000	0	1	1
2001	0	3	3
2003	0	2	2
2008	1	0	1
2011	0	1	1
2014	2	0	2
2016	0	1	1

Below are the most recent publications written about "Replication Protein C" by people in Profiles.

Rhesus monkey TRIM5a protein SPRY domain contributes to AP-1 activation. J Biol Chem. 2018 02 23; 293(8):2661-2674.

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Break-induced telomere synthesis underlies alternative telomere maintenance. Nature. 2016 11 03; 539(7627):54-58.

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Kinetic analysis of PCNA clamp binding and release in the clamp loading reaction catalyzed by Saccharomyces cerevisiae replication factor C. Biochim Biophys Acta. 2015 Jan; 1854(1):31-8.

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Kaposi's sarcoma-associated herpesvirus LANA recruits the DNA polymerase clamp loader to mediate efficient replication and virus persistence. Proc Natl Acad Sci U S A. 2014 Aug 12; 111(32):11816-21.

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Overexpression of RFC3 is correlated with ovarian tumor development and poor prognosis. Tumour Biol. 2014 Oct; 35(10):10259-66.

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Recruitment of Brd4 to the human papillomavirus type 16 DNA replication complex is essential for replication of viral DNA. J Virol. 2013 Apr; 87(7):3871-84.

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Integrative genomics identified RFC3 as an amplified candidate oncogene in esophageal adenocarcinoma. Clin Cancer Res. 2012 Apr 01; 18(7):1936-46.

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BRCA1 is required for postreplication repair after UV-induced DNA damage. Mol Cell. 2011 Oct 21; 44(2):235-51.

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Inhibiting activator protein-1 activity alters cocaine-induced gene expression and potentiates sensitization. Neuroscience. 2008 Apr 09; 152(4):1040-53.

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Replication protein A-mediated recruitment and activation of Rad17 complexes. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):13827-32.

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