Integrin alpha4

"Integrin alpha4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An integrin alpha subunit that is unique in that it does not contain an I domain, and its proteolytic cleavage site is near the middle of the extracellular portion of the polypeptide rather than close to the membrane as in other integrin alpha subunits.

Descriptor ID

D039441

MeSH Number(s)

D12.776.543.750.705.408.100.450

D23.050.301.264.035.291

D23.101.100.110.292

Concept/Terms

Integrin alpha4

Below are MeSH descriptors whose meaning is more general than "Integrin alpha4".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Immunologic [D12.776.543.750.705]
Integrins [D12.776.543.750.705.408]
Integrin alpha Chains [D12.776.543.750.705.408.100]
Integrin alpha4 [D12.776.543.750.705.408.100.450]
Biological Factors [D23]
Antigens [D23.050]
Antigens, Surface [D23.050.301]
Antigens, Differentiation [D23.050.301.264]
Antigens, CD [D23.050.301.264.035]
Integrin alpha4 [D23.050.301.264.035.291]
Biological Markers [D23.101]
Antigens, Differentiation [D23.101.100]
Antigens, CD [D23.101.100.110]
Integrin alpha4 [D23.101.100.110.292]

Below are MeSH descriptors whose meaning is related to "Integrin alpha4".

Below are MeSH descriptors whose meaning is more specific than "Integrin alpha4".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Integrin alpha4" by people in Harvard Catalyst Profiles by year, and whether "Integrin alpha4" was a major or minor topic of these publication.

Bar chart showing 59 publications over 23 distinct years, with a maximum of 6 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	1	1
1995	0	4	4
1996	0	2	2
1997	0	3	3
1998	0	4	4
1999	0	1	1
2001	0	3	3
2002	0	2	2
2003	3	1	4
2004	1	0	1
2005	2	1	3
2006	1	2	3
2008	4	0	4
2009	2	0	2
2010	0	1	1
2011	0	4	4
2012	1	0	1
2013	3	3	6
2014	1	2	3
2015	1	0	1
2018	1	1	2
2019	1	1	2
2021	1	1	2

Below are the most recent publications written about "Integrin alpha4" by people in Profiles.

CD49d marks Th1 and Tfh-like antigen-specific CD4+ T cells during Plasmodium chabaudi infection. Int Immunol. 2021 07 23; 33(8):409-422.

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Conformation-sensitive targeting of lipid nanoparticles for RNA therapeutics. Nat Nanotechnol. 2021 09; 16(9):1030-1038.

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CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome. Nat Commun. 2019 12 18; 10(1):5779.

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Lack of therapeutic efficacy of an antibody to a4ß7 in SIVmac251-infected rhesus macaques. Science. 2019 09 06; 365(6457):1029-1033.

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Glutaredoxin 1 up-regulates deglutathionylation of a4 integrin and thereby restricts neutrophil mobilization from bone marrow. J Biol Chem. 2019 02 22; 294(8):2616-2627.

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Age-related tumor growth in mice is related to integrin a 4 in CD8+ T cells. JCI Insight. 2018 11 02; 3(21).

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Th1 effector T cells selectively orchestrate cardiac fibrosis in nonischemic heart failure. J Exp Med. 2017 Nov 06; 214(11):3311-3329.

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A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity. Nat Immunol. 2017 06; 18(6):654-664.

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a4-Integrin Antibody Treatment Blocks Monocyte/Macrophage Traffic to, Vascular Cell Adhesion Molecule-1 Expression in, and Pathology of the Dorsal Root Ganglia in an SIV Macaque Model of HIV-Peripheral Neuropathy. Am J Pathol. 2016 07; 186(7):1754-1761.

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Angiopoietin-like Protein 2 Is a Multistep Regulator of Inflammatory Neovascularization in a Murine Model of Age-related Macular Degeneration. J Biol Chem. 2016 Apr 01; 291(14):7373-85.

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