"Complement C1q" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subcomponent of complement C1, composed of six copies of three polypeptide chains (A, B, and C), each encoded by a separate gene (C1QA; C1QB; C1QC). This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY.
MeSH Number(s)
D12.776.124.486.274.050.270
Concept/Terms
Complement C1q- Complement C1q
- C1q, Complement
- Complement Component 1q
- Component 1q, Complement
- C1q Complement
- Complement, C1q
- Complement 1q
Below are MeSH descriptors whose meaning is more general than "Complement C1q".
Below are MeSH descriptors whose meaning is more specific than "Complement C1q".
This graph shows the total number of publications written about "Complement C1q" by people in Harvard Catalyst Profiles by year, and whether "Complement C1q" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 1 | 0 | 1 |
1996 | 0 | 1 | 1 |
1997 | 1 | 2 | 3 |
1998 | 1 | 0 | 1 |
1999 | 3 | 0 | 3 |
2000 | 2 | 1 | 3 |
2001 | 0 | 1 | 1 |
2002 | 1 | 0 | 1 |
2003 | 1 | 0 | 1 |
2004 | 2 | 1 | 3 |
2005 | 1 | 1 | 2 |
2006 | 0 | 2 | 2 |
2007 | 1 | 2 | 3 |
2008 | 1 | 1 | 2 |
2009 | 0 | 2 | 2 |
2010 | 1 | 0 | 1 |
2011 | 2 | 3 | 5 |
2012 | 0 | 1 | 1 |
2013 | 1 | 2 | 3 |
2015 | 1 | 0 | 1 |
2016 | 3 | 1 | 4 |
2017 | 0 | 2 | 2 |
2019 | 2 | 2 | 4 |
2020 | 1 | 3 | 4 |
2021 | 2 | 0 | 2 |
2022 | 0 | 1 | 1 |
2023 | 0 | 1 | 1 |
Below are the most recent publications written about "Complement C1q" by people in Profiles.
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Complement C1q essential for aeroallergen sensitization via CSF1R+ conventional dendritic cells type 2. J Allergy Clin Immunol. 2023 11; 152(5):1141-1152.e2.
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Neutrophil heterogeneity in complement C1q expression associated with sepsis mortality. Front Immunol. 2022; 13:965305.
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Retinal Ganglion Cell Axon Regeneration Requires Complement and Myeloid Cell Activity within the Optic Nerve. J Neurosci. 2021 10 13; 41(41):8508-8531.
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Complement Plays a Critical Role in Inflammation-Induced Immunoprophylaxis Failure in Mice. Front Immunol. 2021; 12:704072.
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Renal deposits of complement factors as predictors of end-stage renal disease and death in patients with lupus nephritis. Rheumatology (Oxford). 2020 12 01; 59(12):3751-3758.
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Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency. Nature. 2020 12; 588(7838):459-465.
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Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia. EMBO J. 2020 08 17; 39(16):e105380.
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Development of the clinical candidate PBD-C06, a humanized pGlu3-Aß-specific antibody against Alzheimer's disease with reduced complement activation. Sci Rep. 2020 02 24; 10(1):3294.
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High Prevalence and Disease Correlation of Autoantibodies Against p40 Encoded by Long Interspersed Nuclear Elements in Systemic Lupus Erythematosus. Arthritis Rheumatol. 2020 01; 72(1):89-99.
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Progranulin deficiency leads to enhanced age-related cardiac hypertrophy through complement C1q-induced ß-catenin activation. J Mol Cell Cardiol. 2020 01; 138:197-211.