"Methylmalonic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
Below are MeSH descriptors whose meaning is more general than "Methylmalonic Acid".
Below are MeSH descriptors whose meaning is more specific than "Methylmalonic Acid".
This graph shows the total number of publications written about "Methylmalonic Acid" by people in Harvard Catalyst Profiles by year, and whether "Methylmalonic Acid" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1996 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 1999 | 1 | 0 | 1 |
| 2000 | 2 | 1 | 3 |
| 2001 | 1 | 1 | 2 |
| 2002 | 1 | 0 | 1 |
| 2005 | 2 | 0 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 2 | 0 | 2 |
| 2008 | 3 | 0 | 3 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 1 | 3 | 4 |
| 2018 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 1 | 2 |
| 2022 | 0 | 3 | 3 |
Below are the most recent publications written about "Methylmalonic Acid" by people in Profiles.
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In vivo assignment of methylmalonic acid in breast tissue using 2D MRS and relationship with breast density, menopausal status and cancer risk. NMR Biomed. 2023 03; 36(3):e4851.
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Altered propionate metabolism contributes to tumour progression and aggressiveness. Nat Metab. 2022 04; 4(4):435-443.
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Review of neuropsychological outcomes in isolated methylmalonic acidemia: recommendations for assessing impact of treatments. Metab Brain Dis. 2022 06; 37(5):1317-1335.
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Genetic variants modify the associations of concentrations of methylmalonic acid, vitamin B-12, vitamin B-6, and folate with bone mineral density. Am J Clin Nutr. 2021 08 02; 114(2):578-587.
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Considerations of expanded carrier screening: Lessons learned from combined malonic and methylmalonic aciduria. Mol Genet Genomic Med. 2021 04; 9(4):e1621.
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Age-induced accumulation of methylmalonic acid promotes tumour progression. Nature. 2020 09; 585(7824):283-287.
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A male case with CDKL5-associated encephalopathy manifesting transient methylmalonic acidemia. Eur J Med Genet. 2018 Aug; 61(8):451-454.
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In the Balance. N Engl J Med. 2018 Jan 18; 378(3):e5.
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Is Serum Methylmalonic Acid a Reliable Biomarker of Vitamin B12 Status in Children with Short Bowel Syndrome: A Case Series. J Pediatr. 2018 01; 192:259-261.
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Effects of metformin versus placebo on vitamin B12 metabolism in non-diabetic breast cancer patients in CCTG MA.32. Breast Cancer Res Treat. 2017 Jul; 164(2):371-378.