Giant Cells, Foreign-Body
"Giant Cells, Foreign-Body" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Multinucleated cells (fused macrophages), characteristic of granulomatous inflammation, which form around exogenous material in the skin. They are similar in appearance to Langhans giant cells (GIANT CELLS, LANGHANS), but foreign-body giant cells have more abundant chromatin and their nuclei are scattered in an irregular pattern in the cytoplasm.
MeSH Number(s)
A11.329.372.376
A11.500.376
A11.627.482.376
A11.733.397.376
A15.382.680.397.376
A15.382.812.522.376
Concept/Terms
Giant Cells, Foreign-Body- Giant Cells, Foreign-Body
- Cell, Foreign-Body Giant
- Cells, Foreign-Body Giant
- Foreign-Body Giant Cell
- Foreign-Body Giant Cells
- Giant Cell, Foreign-Body
- Giant Cells, Foreign Body
- Foreign Body Giant Cell
- Foreign Body Giant Cells
- Foreign Body-Type Giant Cells
- Foreign Body Type Giant Cells
Below are MeSH descriptors whose meaning is more general than "Giant Cells, Foreign-Body".
Below are MeSH descriptors whose meaning is more specific than "Giant Cells, Foreign-Body".
This graph shows the total number of publications written about "Giant Cells, Foreign-Body" by people in Harvard Catalyst Profiles by year, and whether "Giant Cells, Foreign-Body" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
Below are the most recent publications written about "Giant Cells, Foreign-Body" by people in Profiles.
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Mechanotransduction via a TRPV4-Rac1 signaling axis plays a role in multinucleated giant cell formation. J Biol Chem. 2021 Jan-Jun; 296:100129.
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Transient Receptor Potential Vanilloid 4 Is Required for Foreign Body Response and Giant Cell Formation. Am J Pathol. 2019 08; 189(8):1505-1512.
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Tumor necrosis factor receptor-associated factor 6 is required to inhibit foreign body giant cell formation and activate osteoclasts under inflammatory and infectious conditions. J Bone Miner Metab. 2018 Nov; 36(6):679-690.
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In vivo response to decellularized mesothelium scaffolds. J Biomed Mater Res B Appl Biomater. 2018 02; 106(2):716-725.
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Interleukin-1 receptor-associated kinase-4 (IRAK4) promotes inflammatory osteolysis by activating osteoclasts and inhibiting formation of foreign body giant cells. J Biol Chem. 2015 Jan 09; 290(2):716-26.
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Alveolar ridge reconstruction with a composite alloplastic biomaterial. Int J Periodontics Restorative Dent. 2012 Dec; 32(6):e204-9.
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An essential role for STAT6-STAT1 protein signaling in promoting macrophage cell-cell fusion. J Biol Chem. 2012 Sep 21; 287(39):32479-84.
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Osteoclast stimulatory transmembrane protein and dendritic cell–specific transmembrane protein cooperatively modulate cell–cell fusion to form osteoclasts and foreign body giant cells. J Bone Miner Res. 2012 Jun; 27(6):1289-97.
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Superficial topography and porosity of an absorbable barrier membrane impacts soft tissue response in guided bone regeneration. J Periodontol. 2010 Jun; 81(6):926-33.
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Macrophage fusion leading to foreign body giant cell formation persists under phagocytic stimulation by microspheres in vitro and in vivo in mouse models. J Biomed Mater Res A. 2010 Apr; 93(1):189-99.