"Genes, abl" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Retrovirus-associated DNA sequences (abl) originally isolated from the Abelson murine leukemia virus (Ab-MuLV). The proto-oncogene abl (c-abl) codes for a protein that is a member of the tyrosine kinase family. The human c-abl gene is located at 9q34.1 on the long arm of chromosome 9. It is activated by translocation to bcr on chromosome 22 in chronic myelogenous leukemia.
MeSH Number(s)
G05.360.340.024.340.375.500.791.100
Concept/Terms
bcr-v-abl Oncogenes- bcr-v-abl Oncogenes
- Oncogene, bcr-v-abl
- Oncogenes, bcr-v-abl
- bcr v abl Oncogenes
- bcr-v-abl Oncogene
abl Oncogene- abl Oncogene
- Oncogene, abl
- Oncogenes, abl
- abl Oncogenes
- v-abl Oncogenes
- Oncogene, v-abl
- Oncogenes, v-abl
- v abl Oncogenes
- v-abl Oncogene
- v-abl Genes
- Gene, v-abl
- Genes, v-abl
- v abl Genes
- v-abl Gene
bcr-abl Proto-Oncogenes- bcr-abl Proto-Oncogenes
- Proto-Oncogene, bcr-abl
- Proto-Oncogenes, bcr-abl
- bcr abl Proto Oncogenes
- bcr-abl Proto-Oncogene
c-abl Genes- c-abl Genes
- Gene, c-abl
- Genes, c-abl
- c abl Genes
- c-abl Gene
- c-abl Proto-Oncogenes
- Proto-Oncogene, c-abl
- Proto-Oncogenes, c-abl
- c abl Proto Oncogenes
- c-abl Proto-Oncogene
Below are MeSH descriptors whose meaning is more general than "Genes, abl".
Below are MeSH descriptors whose meaning is more specific than "Genes, abl".
This graph shows the total number of publications written about "Genes, abl" by people in Harvard Catalyst Profiles by year, and whether "Genes, abl" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1995 | 4 | 0 | 4 |
| 1997 | 2 | 2 | 4 |
| 1998 | 0 | 2 | 2 |
| 1999 | 1 | 0 | 1 |
| 2000 | 1 | 3 | 4 |
| 2001 | 3 | 4 | 7 |
| 2002 | 1 | 2 | 3 |
| 2003 | 0 | 1 | 1 |
| 2004 | 2 | 1 | 3 |
| 2005 | 0 | 1 | 1 |
| 2006 | 3 | 0 | 3 |
| 2007 | 2 | 1 | 3 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 0 | 2 | 2 |
| 2013 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
Below are the most recent publications written about "Genes, abl" by people in Profiles.
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An ultra-long circulating nanoparticle for reviving a highly selective BCR-ABL inhibitor in long-term effective and safe treatment of chronic myeloid leukemia. Nanomedicine. 2020 10; 29:102283.
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Genetic and Chemical Screenings Identify HDAC3 as a Key Regulator in Hepatic Differentiation of Human Pluripotent Stem Cells. Stem Cell Reports. 2018 07 10; 11(1):22-31.
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Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia. Nat Med. 2017 Jun; 23(6):692-702.
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Normal ABL1 is a tumor suppressor and therapeutic target in human and mouse leukemias expressing oncogenic ABL1 kinases. Blood. 2016 04 28; 127(17):2131-43.
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Dissecting the role of aberrant DNA methylation in human leukaemia. Nat Commun. 2015 May 22; 6:7091.
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Differential regulation of myeloid leukemias by the bone marrow microenvironment. Nat Med. 2013 Nov; 19(11):1513-7.
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Structure and dynamic regulation of Abl kinases. J Biol Chem. 2013 Feb 22; 288(8):5443-50.
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[Molecular mechanisms underlying leukemic transformation of myelodysplastic syndromes (MDS) and chronic myelogenous leukemia (CML)]. Rinsho Ketsueki. 2012 Aug; 53(8):734-9.
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The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells. Nat Genet. 2012 Jul 15; 44(8):861-71.
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Predictive value of early molecular response in patients with chronic myeloid leukemia treated with first-line dasatinib. Blood. 2012 Jul 12; 120(2):291-4.