Microphthalmia-Associated Transcription Factor
"Microphthalmia-Associated Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A basic helix-loop-helix leucine zipper transcription factor that regulates the CELL DIFFERENTIATION and development of a variety of cell types including MELANOCYTES; OSTEOCLASTS; and RETINAL PIGMENT EPITHELIUM. Mutations in MITF protein have been associated with OSTEOPETROSIS and WAARDENBURG'S SYNDROME.
MeSH Number(s)
D12.776.260.103.500.500
D12.776.260.108.092.500
D12.776.930.125.500.500
D12.776.930.127.092.500
Concept/Terms
Microphthalmia-Associated Transcription Factor- Microphthalmia-Associated Transcription Factor
- Microphthalmia Associated Transcription Factor
- Transcription Factor, Microphthalmia-Associated
- MITF Transcription Factor
- Transcription Factor Microphthalmia
- Microphthalmia, Transcription Factor
- MITF Protein
Below are MeSH descriptors whose meaning is more general than "Microphthalmia-Associated Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "Microphthalmia-Associated Transcription Factor".
This graph shows the total number of publications written about "Microphthalmia-Associated Transcription Factor" by people in Harvard Catalyst Profiles by year, and whether "Microphthalmia-Associated Transcription Factor" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 3 | 3 |
| 2002 | 0 | 3 | 3 |
| 2003 | 0 | 4 | 4 |
| 2004 | 0 | 6 | 6 |
| 2005 | 0 | 4 | 4 |
| 2006 | 4 | 2 | 6 |
| 2007 | 2 | 1 | 3 |
| 2008 | 2 | 2 | 4 |
| 2009 | 1 | 4 | 5 |
| 2010 | 4 | 3 | 7 |
| 2011 | 7 | 0 | 7 |
| 2012 | 4 | 2 | 6 |
| 2013 | 2 | 2 | 4 |
| 2014 | 3 | 6 | 9 |
| 2015 | 6 | 1 | 7 |
| 2016 | 3 | 4 | 7 |
| 2017 | 1 | 4 | 5 |
| 2018 | 6 | 0 | 6 |
| 2019 | 4 | 1 | 5 |
| 2020 | 6 | 4 | 10 |
| 2021 | 1 | 0 | 1 |
| 2022 | 2 | 1 | 3 |
| 2023 | 1 | 1 | 2 |
Below are the most recent publications written about "Microphthalmia-Associated Transcription Factor" by people in Profiles.
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Clear cell tumor with melanocytic differentiation and MITF::CREM translocation. J Cutan Pathol. 2023 Jul; 50(7):619-622.
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A central role for regulated protein stability in the control of TFE3 and MITF by nutrients. Mol Cell. 2023 01 05; 83(1):57-73.e9.
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DNA promoter hypermethylation of melanocyte lineage genes determines melanoma phenotype. JCI Insight. 2022 10 10; 7(19).
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Fate mapping melanoma persister cells through regression and into recurrent disease in adult zebrafish. Dis Model Mech. 2022 09 01; 15(9).
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Vulvar Melanoma in association with germline MITF p.E318K variant. Cancer Genet. 2022 04; 262-263:102-106.
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Integrative clinical and molecular characterization of translocation renal cell carcinoma. Cell Rep. 2022 01 04; 38(1):110190.
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NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism. Cell. 2021 08 05; 184(16):4268-4283.e20.
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CYP27A1-dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism. Cell Chem Biol. 2021 10 21; 28(10):1407-1419.e6.
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Skin pigmentation and its control: From ultraviolet radiation to stem cells. Exp Dermatol. 2021 04; 30(4):560-571.
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MITF functions as a tumor suppressor in non-small cell lung cancer beyond the canonically oncogenic role. Aging (Albany NY). 2020 12 03; 13(1):646-674.