GTP-Binding Protein alpha Subunit, Gi2
"GTP-Binding Protein alpha Subunit, Gi2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A PERTUSSIS TOXIN-sensitive GTP-binding protein alpha subunit. It couples with a variety of CELL SURFACE RECEPTORS, has been implicated in INTERLEUKIN-12 production, and may play a role in INFLAMMATORY BOWEL DISEASES.
MeSH Number(s)
D08.811.277.040.330.300.200.100.200.500
D12.644.360.375.100.200.500
D12.776.157.325.332.100.200.500
D12.776.476.375.100.200.500
D12.776.543.325.100.200.500
Concept/Terms
GTP-Binding Protein alpha Subunit, Gi2- GTP-Binding Protein alpha Subunit, Gi2
- GTP Binding Protein alpha Subunit, Gi2
- Galpha(i2) Protein
- Gi2-alpha Protein
- Gi2 alpha Protein
- G Protein Subunit alpha I2
- Galphai2 Protein
Below are MeSH descriptors whose meaning is more general than "GTP-Binding Protein alpha Subunit, Gi2".
- Chemicals and Drugs [D]
- Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
- Hydrolases [D08.811.277]
- Acid Anhydride Hydrolases [D08.811.277.040]
- GTP Phosphohydrolases [D08.811.277.040.330]
- GTP-Binding Proteins [D08.811.277.040.330.300]
- Heterotrimeric GTP-Binding Proteins [D08.811.277.040.330.300.200]
- GTP-Binding Protein alpha Subunits [D08.811.277.040.330.300.200.100]
- GTP-Binding Protein alpha Subunits, Gi-Go [D08.811.277.040.330.300.200.100.200]
- GTP-Binding Protein alpha Subunit, Gi2 [D08.811.277.040.330.300.200.100.200.500]
- Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
- Intracellular Signaling Peptides and Proteins [D12.644.360]
- Heterotrimeric GTP-Binding Proteins [D12.644.360.375]
- GTP-Binding Protein alpha Subunits [D12.644.360.375.100]
- GTP-Binding Protein alpha Subunits, Gi-Go [D12.644.360.375.100.200]
- GTP-Binding Protein alpha Subunit, Gi2 [D12.644.360.375.100.200.500]
- Proteins [D12.776]
- Carrier Proteins [D12.776.157]
- GTP-Binding Proteins [D12.776.157.325]
- Heterotrimeric GTP-Binding Proteins [D12.776.157.325.332]
- GTP-Binding Protein alpha Subunits [D12.776.157.325.332.100]
- GTP-Binding Protein alpha Subunits, Gi-Go [D12.776.157.325.332.100.200]
- GTP-Binding Protein alpha Subunit, Gi2 [D12.776.157.325.332.100.200.500]
- Intracellular Signaling Peptides and Proteins [D12.776.476]
- Heterotrimeric GTP-Binding Proteins [D12.776.476.375]
- GTP-Binding Protein alpha Subunits [D12.776.476.375.100]
- GTP-Binding Protein alpha Subunits, Gi-Go [D12.776.476.375.100.200]
- GTP-Binding Protein alpha Subunit, Gi2 [D12.776.476.375.100.200.500]
- Membrane Proteins [D12.776.543]
- Heterotrimeric GTP-Binding Proteins [D12.776.543.325]
- GTP-Binding Protein alpha Subunits [D12.776.543.325.100]
- GTP-Binding Protein alpha Subunits, Gi-Go [D12.776.543.325.100.200]
- GTP-Binding Protein alpha Subunit, Gi2 [D12.776.543.325.100.200.500]
Below are MeSH descriptors whose meaning is more specific than "GTP-Binding Protein alpha Subunit, Gi2".
This graph shows the total number of publications written about "GTP-Binding Protein alpha Subunit, Gi2" by people in Harvard Catalyst Profiles by year, and whether "GTP-Binding Protein alpha Subunit, Gi2" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
---|
1996 | 0 | 2 | 2 |
1997 | 0 | 1 | 1 |
1998 | 0 | 1 | 1 |
1999 | 0 | 1 | 1 |
2000 | 0 | 1 | 1 |
2001 | 0 | 3 | 3 |
2002 | 0 | 3 | 3 |
2005 | 0 | 1 | 1 |
2006 | 1 | 1 | 2 |
2007 | 1 | 1 | 2 |
2010 | 2 | 1 | 3 |
2011 | 1 | 3 | 4 |
2012 | 0 | 1 | 1 |
2013 | 1 | 0 | 1 |
2014 | 0 | 1 | 1 |
2018 | 2 | 0 | 2 |
2020 | 1 | 0 | 1 |
Below are the most recent publications written about "GTP-Binding Protein alpha Subunit, Gi2" by people in Profiles.
-
Hypothalamic Paraventricular Nucleus Gai2 (Guanine Nucleotide-Binding Protein Alpha Inhibiting Activity Polypeptide 2) Protein-Mediated Neural Control of the Kidney and the Salt Sensitivity of Blood Pressure. Hypertension. 2020 04; 75(4):1002-1011.
-
Gai Proteins are Indispensable for Hearing. Cell Physiol Biochem. 2018; 47(4):1509-1532.
-
GNAI2 polymorphic variance associates with salt sensitivity of blood pressure in the Genetic Epidemiology Network of Salt Sensitivity study. Physiol Genomics. 2018 09 01; 50(9):724-725.
-
The GPSM2/LGN GoLoco motifs are essential for hearing. Mamm Genome. 2016 Feb; 27(1-2):29-46.
-
An essential role for Ga(i2) in Smoothened-stimulated epithelial cell proliferation in the mammary gland. Sci Signal. 2015 Sep 15; 8(394):ra92.
-
Platelet Gi protein Gai2 is an essential mediator of thrombo-inflammatory organ damage in mice. Proc Natl Acad Sci U S A. 2015 May 19; 112(20):6491-6.
-
5-HT1A receptor-mediated phosphorylation of extracellular signal-regulated kinases (ERK1/2) is modulated by regulator of G protein signaling protein 19. Cell Signal. 2014 Sep; 26(9):1846-52.
-
Gai2 signaling is required for skeletal muscle growth, regeneration, and satellite cell proliferation and differentiation. Mol Cell Biol. 2014 Feb; 34(4):619-30.
-
IEX-1 deficiency protects against colonic cancer. Mol Cancer Res. 2012 Jun; 10(6):760-7.
-
Tumor progression locus 2 mediates signal-induced increases in cytoplasmic calcium and cell migration. Sci Signal. 2011 Aug 23; 4(187):ra55.