"Glucosylceramidase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A glycosidase that hydrolyzes a glucosylceramide to yield free ceramide plus glucose. Deficiency of this enzyme leads to abnormally high concentrations of glucosylceramide in the brain in GAUCHER DISEASE. EC 3.2.1.45.
MeSH Number(s)
D08.811.277.450.420.475.400
Concept/Terms
Glucosylceramidase- Glucosylceramidase
- Glucocerebrosidase
- Glucocerebroside beta-Glucosidase
- Glucocerebroside beta Glucosidase
- beta-Glucosidase, Glucocerebroside
- Glucosyl Ceramidase
- Ceramidase, Glucosyl
- Glucosylceramide beta-Glucosidase
- Glucosylceramide beta Glucosidase
- beta-Glucosidase, Glucosylceramide
- Glucosylsphingosine Glucosyl Hydrolase
- Glucosyl Hydrolase, Glucosylsphingosine
- Hydrolase, Glucosylsphingosine Glucosyl
- Acid beta-Glucosidase
- Acid beta Glucosidase
- beta-Glucosidase, Acid
- beta-Glucocerebrosidase
- beta Glucocerebrosidase
Below are MeSH descriptors whose meaning is more general than "Glucosylceramidase".
Below are MeSH descriptors whose meaning is more specific than "Glucosylceramidase".
This graph shows the total number of publications written about "Glucosylceramidase" by people in Harvard Catalyst Profiles by year, and whether "Glucosylceramidase" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 1 | 1 | 2 |
1995 | 1 | 1 | 2 |
1996 | 1 | 0 | 1 |
1998 | 0 | 1 | 1 |
2002 | 2 | 0 | 2 |
2004 | 1 | 0 | 1 |
2006 | 1 | 0 | 1 |
2008 | 1 | 0 | 1 |
2009 | 3 | 1 | 4 |
2010 | 4 | 1 | 5 |
2012 | 3 | 1 | 4 |
2013 | 1 | 1 | 2 |
2014 | 2 | 3 | 5 |
2015 | 4 | 1 | 5 |
2016 | 5 | 2 | 7 |
2017 | 1 | 0 | 1 |
2018 | 4 | 2 | 6 |
2019 | 2 | 2 | 4 |
2020 | 3 | 4 | 7 |
2021 | 5 | 3 | 8 |
2022 | 1 | 2 | 3 |
2023 | 1 | 4 | 5 |
Below are the most recent publications written about "Glucosylceramidase" by people in Profiles.
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Loss of Lipid Carrier ApoE Exacerbates Brain Glial and Inflammatory Responses after Lysosomal GBA1 Inhibition. Cells. 2023 11 02; 12(21).
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Acid ceramidase involved in pathogenic cascade leading to accumulation of a-synuclein in iPSC model of GBA1-associated Parkinson's disease. Hum Mol Genet. 2023 05 18; 32(11):1888-1900.
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A Phase 1B Trial in GBA1-Associated Parkinson's Disease of BIA-28-6156, a Glucocerebrosidase Activator. Mov Disord. 2023 07; 38(7):1197-1208.
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Differences in Sex-Specific Frequency of Glucocerebrosidase Variant Carriers and Familial Parkinsonism. Mov Disord. 2023 04; 38(4):714-715.
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A Biomarker Study in Patients with GBA1-Parkinson's Disease and Healthy Controls. Mov Disord. 2023 05; 38(5):783-795.
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Differences in Sex-Specific Frequency of Glucocerebrosidase Variant Carriers and Familial Parkinsonism. Mov Disord. 2022 11; 37(11):2217-2225.
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What to Test in Parkinson Disease Prevention Trials? Repurposed, Low-Risk, and Gene-Targeted Drugs. Neurology. 2022 08 16; 99(7 Suppl 1):34-41.
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GBA and APOE Impact Cognitive Decline in Parkinson's Disease: A 10-Year Population-Based Study. Mov Disord. 2022 05; 37(5):1016-1027.
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Assessment of Glucocerebrosidase Enzyme Activity in Parkinson Disease Using Multiple Approaches. Mov Disord. 2022 03; 37(3):655-656.
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Safety, Pharmacokinetics, and Pharmacodynamics of Oral Venglustat in Patients with Parkinson's Disease and a GBA Mutation: Results from Part 1 of the Randomized, Double-Blinded, Placebo-Controlled MOVES-PD Trial. J Parkinsons Dis. 2022; 12(2):557-570.