Heterogeneous-Nuclear Ribonucleoprotein K

"Heterogeneous-Nuclear Ribonucleoprotein K" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A heterogeneous-nuclear ribonucleoprotein found in the CELL NUCLEUS and the CYTOPLASM. Heterogeneous-nuclear ribonucleoprotein K has been implicated in the regulation of gene expression at nearly all levels: GENETIC TRANSCRIPTION; mRNA processing (RNA PROCESSING, POST-TRANSCRIPTIONAL), mRNA transport, mRNA stability, and translation (TRANSLATION, GENETIC). The hnRNP protein has a strong affinity for polypyrimidine-rich RNA and for single-stranded polypyrimidine-rich DNA. Multiple hnRNP K protein isoforms exist due to alternative splicing and display different nucleic-acid-binding properties.

Descriptor ID

D034641

MeSH Number(s)

D12.776.157.725.500.500.500

D12.776.260.268

D12.776.664.962.500.500.500

Concept/Terms

Heterogeneous-Nuclear Ribonucleoprotein K

hnRNP K Protein

Below are MeSH descriptors whose meaning is more general than "Heterogeneous-Nuclear Ribonucleoprotein K".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
RNA-Binding Proteins [D12.776.157.725]
Ribonucleoproteins [D12.776.157.725.500]
Heterogeneous-Nuclear Ribonucleoproteins [D12.776.157.725.500.500]
Heterogeneous-Nuclear Ribonucleoprotein K [D12.776.157.725.500.500.500]
DNA-Binding Proteins [D12.776.260]
Heterogeneous-Nuclear Ribonucleoprotein K [D12.776.260.268]
Nucleoproteins [D12.776.664]
RNA-Binding Proteins [D12.776.664.962]
Ribonucleoproteins [D12.776.664.962.500]
Heterogeneous-Nuclear Ribonucleoproteins [D12.776.664.962.500.500]
Heterogeneous-Nuclear Ribonucleoprotein K [D12.776.664.962.500.500.500]

Below are MeSH descriptors whose meaning is related to "Heterogeneous-Nuclear Ribonucleoprotein K".

Below are MeSH descriptors whose meaning is more specific than "Heterogeneous-Nuclear Ribonucleoprotein K".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Heterogeneous-Nuclear Ribonucleoprotein K" by people in Harvard Catalyst Profiles by year, and whether "Heterogeneous-Nuclear Ribonucleoprotein K" was a major or minor topic of these publication.

Bar chart showing 12 publications over 10 distinct years, with a maximum of 2 publications in 2017 and 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2006	1	0	1
2009	1	0	1
2010	0	1	1
2011	1	0	1
2012	0	1	1
2014	0	1	1
2015	0	1	1
2017	2	0	2
2019	1	1	2
2022	0	1	1

Below are the most recent publications written about "Heterogeneous-Nuclear Ribonucleoprotein K" by people in Profiles.

An HNRNPK-specific DNA methylation signature makes sense of missense variants and expands the phenotypic spectrum of Au-Kline syndrome. Am J Hum Genet. 2022 Oct 06; 109(10):1867-1884.

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The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis. Nucleic Acids Res. 2020 03 18; 48(5):2621-2642.

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Xist Deletional Analysis Reveals an Interdependency between Xist RNA and Polycomb Complexes for Spreading along the Inactive X. Mol Cell. 2019 04 04; 74(1):101-117.e10.

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O-GlcNAc-induced nuclear translocation of hnRNP-K is associated with progression and metastasis of cholangiocarcinoma. Mol Oncol. 2019 02; 13(2):338-357.

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The Neuroprotective Marine Compound Psammaplysene A Binds the RNA-Binding Protein HNRNPK. Mar Drugs. 2017 Aug 07; 15(8).

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Insulin Inhibits Nrf2 Gene Expression via Heterogeneous Nuclear Ribonucleoprotein F/K in Diabetic Mice. Endocrinology. 2017 04 01; 158(4):903-919.

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RING1B O-GlcNAcylation regulates gene targeting of polycomb repressive complex 1 in human embryonic stem cells. Stem Cell Res. 2015 Jul; 15(1):182-9.

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Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis. J Clin Invest. 2014 Dec; 124(12):5275-90.

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Identification and functional characterization of nuclear mortalin in human carcinogenesis. J Biol Chem. 2014 Sep 05; 289(36):24832-44.

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Granzyme M targets host cell hnRNP K that is essential for human cytomegalovirus replication. Cell Death Differ. 2013 Mar; 20(3):419-29.

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