Replication Origin

"Replication Origin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A unique DNA sequence of a replicon at which DNA REPLICATION is initiated and proceeds bidirectionally or unidirectionally. It contains the sites where the first separation of the complementary strands occurs, a primer RNA is synthesized, and the switch from primer RNA to DNA synthesis takes place. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)

Descriptor ID

D018741

MeSH Number(s)

G05.360.340.024.220.760

G05.360.340.024.745.725

Concept/Terms

Replication Origin

Below are MeSH descriptors whose meaning is more general than "Replication Origin".

Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Genome [G05.360.340]
Genome Components [G05.360.340.024]
DNA, Intergenic [G05.360.340.024.220]
Replication Origin [G05.360.340.024.220.760]
Replicon [G05.360.340.024.745]
Replication Origin [G05.360.340.024.745.725]

Below are MeSH descriptors whose meaning is related to "Replication Origin".

Below are MeSH descriptors whose meaning is more specific than "Replication Origin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Replication Origin" by people in Harvard Catalyst Profiles by year, and whether "Replication Origin" was a major or minor topic of these publication.

Bar chart showing 68 publications over 28 distinct years, with a maximum of 7 publications in 2002 and 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	1	0	1
1996	0	1	1
1997	0	1	1
1998	1	1	2
1999	0	1	1
2000	1	1	2
2001	0	3	3
2002	3	4	7
2003	1	1	2
2004	1	4	5
2005	2	3	5
2006	2	1	3
2007	0	1	1
2008	0	3	3
2009	1	1	2
2010	0	2	2
2011	0	2	2
2012	0	2	2
2013	0	2	2
2014	1	6	7
2015	1	1	2
2016	0	2	2
2017	0	2	2
2018	1	1	2
2019	1	1	2
2020	1	1	2
2021	1	0	1
2022	0	1	1

Below are the most recent publications written about "Replication Origin" by people in Profiles.

Comprehensive analysis of DNA replication timing across 184 cell lines suggests a role for MCM10 in replication timing regulation. Hum Mol Genet. 2022 08 25; 31(17):2899-2917.

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Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication. Mol Cell. 2021 02 04; 81(3):426-441.e8.

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Molecular underpinnings of ssDNA specificity by Rep HUH-endonucleases and implications for HUH-tag multiplexing and engineering. Nucleic Acids Res. 2021 01 25; 49(2):1046-1064.

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gammaBOriS: Identification and Taxonomic Classification of Origins of Replication in Gammaproteobacteria using Motif-based Machine Learning. Sci Rep. 2020 04 21; 10(1):6727.

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Arabidopsis DNA Replication Initiates in Intergenic, AT-Rich Open Chromatin. Plant Physiol. 2020 05; 183(1):206-220.

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Frequent template switching in postreplication gaps: suppression of deleterious consequences by the Escherichia coli Uup and RadD proteins. Nucleic Acids Res. 2020 01 10; 48(1):212-230.

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Novel replisome-associated proteins at cellular replication forks in EBV-transformed B lymphocytes. PLoS Pathog. 2019 12; 15(12):e1008228.

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Intrinsic checkpoint deficiency during cell cycle re-entry from quiescence. J Cell Biol. 2019 07 01; 218(7):2169-2184.

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Boolean model of growth signaling, cell cycle and apoptosis predicts the molecular mechanism of aberrant cell cycle progression driven by hyperactive PI3K. PLoS Comput Biol. 2019 03; 15(3):e1006402.

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Rif1 Binding and Control of Chromosome-Internal DNA Replication Origins Is Limited by Telomere Sequestration. Cell Rep. 2018 04 24; 23(4):983-992.

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