Thyrotropin, beta Subunit
"Thyrotropin, beta Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The beta subunit of thyroid stimulating hormone, thyrotropin. It is a 112-amino acid glycopolypeptide of about 16 kD. Full biological activity of TSH requires the non-covalently bound heterodimers of an alpha and a beta subunit.
MeSH Number(s)
D06.472.699.631.525.883.500
D12.644.548.691.525.883.500
Concept/Terms
Thyrotropin, beta Subunit- Thyrotropin, beta Subunit
- Thyrotropin, beta Chain
- Thyroid Stimulating Hormone, beta Subunit
- TSHB Gene Product
- Thyrotropin-beta
- Thyrotropin beta
- TSH, beta Subunit
- TSH-beta
- TSH beta
- TSH, beta Chain
- Thyrotropin, beta Polypeptide Chain
Below are MeSH descriptors whose meaning is more general than "Thyrotropin, beta Subunit".
Below are MeSH descriptors whose meaning is more specific than "Thyrotropin, beta Subunit".
This graph shows the total number of publications written about "Thyrotropin, beta Subunit" by people in Harvard Catalyst Profiles by year, and whether "Thyrotropin, beta Subunit" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
Below are the most recent publications written about "Thyrotropin, beta Subunit" by people in Profiles.
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TSHB mRNA is linked to cholesterol metabolism in adipose tissue. FASEB J. 2017 10; 31(10):4482-4491.
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ISL1 Is Necessary for Maximal Thyrotrope Response to Hypothyroidism. Mol Endocrinol. 2015 Oct; 29(10):1510-21.
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A TSHß Variant with Impaired Immunoreactivity but Intact Biological Activity and Its Clinical Implications. Thyroid. 2015 Aug; 25(8):869-76.
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PITX2 AND PITX1 regulate thyrotroph function and response to hypothyroidism. Mol Endocrinol. 2011 Nov; 25(11):1950-60.
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Pituitary tumors arising from glycoprotein hormone alpha-subunit-deficient mice contain transcription factors and receptors present in thyrotropes. Pituitary. 2006; 9(1):11-8.
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Four new cases of congenital secondary hypothyroidism due to a splice site mutation in the thyrotropin-beta gene: phenotypic variability and founder effect. J Clin Endocrinol Metab. 2004 Aug; 89(8):4136-41.
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Thyroid hormone receptor-specific interactions with steroid receptor coactivator-1 in the pituitary. Mol Endocrinol. 2003 May; 17(5):882-94.
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Domains of Pit-1 required for transcriptional synergy with GATA-2 on the TSH beta gene. Mol Cell Endocrinol. 2002 Oct 31; 196(1-2):53-66.