"C-Peptide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The middle segment of proinsulin that is between the N-terminal B-chain and the C-terminal A-chain. It is a pancreatic peptide of about 31 residues, depending on the species. Upon proteolytic cleavage of proinsulin, equimolar INSULIN and C-peptide are released. C-peptide immunoassay has been used to assess pancreatic beta cell function in diabetic patients with circulating insulin antibodies or exogenous insulin. Half-life of C-peptide is 30 min, almost 8 times that of insulin.
MeSH Number(s)
D06.472.699.587.200.500.250
D12.644.548.586.200.500.250
Concept/Terms
C-Peptide- C-Peptide
- C Peptide
- Connecting Peptide
- Proinsulin C-Peptide
- Proinsulin C Peptide
- C-Peptide, Proinsulin
- C Peptide, Proinsulin
Below are MeSH descriptors whose meaning is more general than "C-Peptide".
Below are MeSH descriptors whose meaning is more specific than "C-Peptide".
This graph shows the total number of publications written about "C-Peptide" by people in Harvard Catalyst Profiles by year, and whether "C-Peptide" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1996 | 0 | 1 | 1 |
1997 | 0 | 1 | 1 |
1998 | 2 | 3 | 5 |
1999 | 0 | 2 | 2 |
2000 | 0 | 3 | 3 |
2001 | 1 | 8 | 9 |
2002 | 0 | 4 | 4 |
2003 | 1 | 10 | 11 |
2004 | 5 | 5 | 10 |
2005 | 5 | 6 | 11 |
2006 | 2 | 3 | 5 |
2007 | 2 | 6 | 8 |
2008 | 3 | 8 | 11 |
2009 | 5 | 2 | 7 |
2010 | 2 | 8 | 10 |
2011 | 4 | 8 | 12 |
2012 | 4 | 6 | 10 |
2013 | 1 | 3 | 4 |
2014 | 2 | 6 | 8 |
2015 | 3 | 3 | 6 |
2016 | 1 | 12 | 13 |
2017 | 0 | 3 | 3 |
2018 | 2 | 8 | 10 |
2019 | 1 | 6 | 7 |
2020 | 1 | 5 | 6 |
2021 | 0 | 4 | 4 |
2022 | 0 | 8 | 8 |
2023 | 0 | 5 | 5 |
2024 | 0 | 1 | 1 |
Below are the most recent publications written about "C-Peptide" by people in Profiles.
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Growth Hormone Mediators and Glycemic Control in Youths With Type 2 Diabetes: A Secondary Analysis of a Randomized Clinical Trial. JAMA Netw Open. 2024 Feb 05; 7(2):e240447.
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Effect of acute altitude exposure on physiological parameters and glucose metabolism in healthy lowland Peruvians. F1000Res. 2023; 12:724.
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The metabolic potential of inflammatory and insulinaemic dietary patterns and risk of type 2 diabetes. Diabetologia. 2024 Jan; 67(1):88-101.
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CRP, C-Peptide, and Risk of First-Time Cardiovascular Events and Mortality in Early Type 2 Diabetes: A Danish Cohort Study. Diabetes Care. 2023 05 01; 46(5):1037-1045.
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Metabolically defined body size and body shape phenotypes and risk of postmenopausal breast cancer in the European Prospective Investigation into Cancer and Nutrition. Cancer Med. 2023 06; 12(11):12668-12682.
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Loss of Visceral Fat is Associated with a Reduction in Inflammatory Status in Patients with Metabolic Syndrome. Mol Nutr Food Res. 2023 02; 67(4):e2200264.
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Fructose consumption from different food sources and cardiometabolic biomarkers: cross-sectional associations in US men and women. Am J Clin Nutr. 2023 03; 117(3):490-498.
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Habitual coffee consumption and subsequent risk of type 2 diabetes in individuals with a history of gestational diabetes - a prospective study. Am J Clin Nutr. 2022 12 19; 116(6):1693-1703.
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The course of C-peptide levels in patients developing diabetes during anti-PD-1 therapy. Biomed Pharmacother. 2022 Dec; 156:113839.
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Targeted proteomics identifies potential biomarkers of dysglycaemia, beta cell function and insulin sensitivity in Black African men and women. Diabetologia. 2023 01; 66(1):174-189.