Adenylate Cyclase Toxin

"Adenylate Cyclase Toxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

One of the virulence factors produced by virulent BORDETELLA organisms. It is a bifunctional protein with both ADENYLATE CYCLASE and hemolysin components.

Descriptor ID

D037361

MeSH Number(s)

D08.811.520.650.200.040

D23.946.123.946.040

D23.946.896.980.040

Concept/Terms

Adenylate Cyclase Toxin

Bordetella pertussis Adenylate Cyclase Toxin

Below are MeSH descriptors whose meaning is more general than "Adenylate Cyclase Toxin".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Lyases [D08.811.520]
Phosphorus-Oxygen Lyases [D08.811.520.650]
Adenylate Cyclase [D08.811.520.650.200]
Adenylate Cyclase Toxin [D08.811.520.650.200.040]
Biological Factors [D23]
Toxins, Biological [D23.946]
Bacterial Toxins [D23.946.123]
Virulence Factors, Bordetella [D23.946.123.946]
Adenylate Cyclase Toxin [D23.946.123.946.040]
Virulence Factors [D23.946.896]
Virulence Factors, Bordetella [D23.946.896.980]
Adenylate Cyclase Toxin [D23.946.896.980.040]

Below are MeSH descriptors whose meaning is related to "Adenylate Cyclase Toxin".

Below are MeSH descriptors whose meaning is more specific than "Adenylate Cyclase Toxin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Adenylate Cyclase Toxin" by people in Harvard Catalyst Profiles by year, and whether "Adenylate Cyclase Toxin" was a major or minor topic of these publication.

Bar chart showing 6 publications over 6 distinct years, with a maximum of 1 publications in 1994 and 1995 and 1998 and 1999 and 2004 and 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	1	1
1995	0	1	1
1998	0	1	1
1999	1	0	1
2004	0	1	1
2010	1	0	1

Below are the most recent publications written about "Adenylate Cyclase Toxin" by people in Profiles.

Block V RTX Domain of Adenylate Cyclase from Bordetella pertussis: A Conformationally Dynamic Scaffold for Protein Engineering Applications. Toxins (Basel). 2017 09 17; 9(9).

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Calcium influx rescues adenylate cyclase-hemolysin from rapid cell membrane removal and enables phagocyte permeabilization by toxin pores. PLoS Pathog. 2012; 8(4):e1002580.

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Calcium-induced folding of a beta roll motif requires C-terminal entropic stabilization. J Mol Biol. 2010 Jul 09; 400(2):244-56.

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Adenylate cyclase toxin translocates across target cell membrane without forming a pore. Mol Microbiol. 2010 Mar; 75(6):1550-62.

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Selective translocation of the Bordetella pertussis adenylate cyclase toxin across the basolateral membranes of polarized epithelial cells. J Biol Chem. 2010 Apr 02; 285(14):10662-70.

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Oligomerization is involved in pore formation by Bordetella adenylate cyclase toxin. FASEB J. 2009 Sep; 23(9):2831-43.

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Segments crucial for membrane translocation and pore-forming activity of Bordetella adenylate cyclase toxin. J Biol Chem. 2007 Apr 27; 282(17):12419-29.

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Third activity of Bordetella adenylate cyclase (AC) toxin-hemolysin. Membrane translocation of AC domain polypeptide promotes calcium influx into CD11b+ monocytes independently of the catalytic and hemolytic activities. J Biol Chem. 2007 Feb 02; 282(5):2808-20.

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Pore-forming and enzymatic activities of Bordetella pertussis adenylate cyclase toxin synergize in promoting lysis of monocytes. Infect Immun. 2006 Apr; 74(4):2207-14.

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Acylation of lysine 860 allows tight binding and cytotoxicity of Bordetella adenylate cyclase on CD11b-expressing cells. Biochemistry. 2005 Sep 27; 44(38):12759-66.

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