SOS1 Protein

"SOS1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A mammalian homolog of the DROSOPHILA SON OF SEVENLESS PROTEIN. It is a guanine nucleotide exchange factor for RAS PROTEINS.

Descriptor ID

D020837

MeSH Number(s)

D12.644.360.325.300.700.700.630

D12.776.402.300.700.700.650

D12.776.476.325.300.700.700.630

Concept/Terms

SOS1 Protein

Below are MeSH descriptors whose meaning is more general than "SOS1 Protein".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
GTP-Binding Protein Regulators [D12.644.360.325]
Guanine Nucleotide Exchange Factors [D12.644.360.325.300]
ras Guanine Nucleotide Exchange Factors [D12.644.360.325.300.700]
Son of Sevenless Proteins [D12.644.360.325.300.700.700]
SOS1 Protein [D12.644.360.325.300.700.700.630]
Proteins [D12.776]
GTP-Binding Protein Regulators [D12.776.402]
Guanine Nucleotide Exchange Factors [D12.776.402.300]
ras Guanine Nucleotide Exchange Factors [D12.776.402.300.700]
Son of Sevenless Proteins [D12.776.402.300.700.700]
SOS1 Protein [D12.776.402.300.700.700.650]
Intracellular Signaling Peptides and Proteins [D12.776.476]
GTP-Binding Protein Regulators [D12.776.476.325]
Guanine Nucleotide Exchange Factors [D12.776.476.325.300]
ras Guanine Nucleotide Exchange Factors [D12.776.476.325.300.700]
Son of Sevenless Proteins [D12.776.476.325.300.700.700]
SOS1 Protein [D12.776.476.325.300.700.700.630]

Below are MeSH descriptors whose meaning is related to "SOS1 Protein".

Below are MeSH descriptors whose meaning is more specific than "SOS1 Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "SOS1 Protein" by people in Harvard Catalyst Profiles by year, and whether "SOS1 Protein" was a major or minor topic of these publication.

Bar chart showing 23 publications over 17 distinct years, with a maximum of 3 publications in 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1997	0	1	1
2003	0	1	1
2004	0	1	1
2006	1	0	1
2007	2	0	2
2008	1	1	2
2010	1	1	2
2011	0	1	1
2012	1	0	1
2013	0	1	1
2015	3	0	3
2016	0	1	1
2017	0	1	1
2018	1	1	2
2019	1	0	1
2020	1	0	1

Below are the most recent publications written about "SOS1 Protein" by people in Profiles.

A high-grade glioma with SOS1 amplification. Clin Neuropathol. 2020 May/Jun; 39(3):126-134.

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The spectrum of genetic variants and phenotypic features of Southeast Asian patients with Noonan syndrome. Mol Genet Genomic Med. 2019 04; 7(4):e00581.

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Identification and Characterization of Oncogenic SOS1 Mutations in Lung Adenocarcinoma. Mol Cancer Res. 2019 04; 17(4):1002-1012.

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Nonreentrant atrial tachycardia occurs independently of hypertrophic cardiomyopathy in RASopathy patients. Am J Med Genet A. 2018 08; 176(8):1711-1722.

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NGS testing for cardiomyopathy: Utility of adding RASopathy-associated genes. Hum Mutat. 2018 07; 39(7):954-958.

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RUNX1 positively regulates the ErbB2/HER2 signaling pathway through modulating SOS1 expression in gastric cancer cells. Sci Rep. 2018 04 23; 8(1):6423.

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FOXI2: a possible gene contributing to ectodermal dysplasia. Eur J Dermatol. 2017 Dec 01; 27(6):641-645.

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Retrospective study of prenatal ultrasound findings in newborns with a Noonan spectrum disorder. Prenat Diagn. 2016 May; 36(5):418-23.

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Coronary artery ectasia in Noonan syndrome: Report of an individual with SOS1 mutation and literature review. Am J Med Genet A. 2016 Mar; 170(3):665-9.

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Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy. Nat Commun. 2015 Jun 16; 6:7247.

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