Glucose-6-Phosphate Isomerase
"Glucose-6-Phosphate Isomerase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.
Concept/Terms
Glucose-6-Phosphate Isomerase- Glucose-6-Phosphate Isomerase
- Glucose 6 Phosphate Isomerase
- Isomerase, Glucose-6-Phosphate
- Isomerase, Glucose 6 Phosphate
- Phosphohexose Isomerase
- Isomerase, Phosphohexose
- Glucosephosphate Isomerase
- Isomerase, Glucosephosphate
- Phosphoglucose Isomerase
- Isomerase, Phosphoglucose
Autocrine Motility Factor- Autocrine Motility Factor
- Motility Factor, Autocrine
- Tumor Autocrine Motility Factor
- Tumor-Cell Autocrine Motility Factor
- Tumor Cell Autocrine Motility Factor
- Neuroleukin
Below are MeSH descriptors whose meaning is more general than "Glucose-6-Phosphate Isomerase".
Below are MeSH descriptors whose meaning is more specific than "Glucose-6-Phosphate Isomerase".
This graph shows the total number of publications written about "Glucose-6-Phosphate Isomerase" by people in Harvard Catalyst Profiles by year, and whether "Glucose-6-Phosphate Isomerase" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 1 | 2 |
| 1995 | 0 | 2 | 2 |
| 1999 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2002 | 3 | 0 | 3 |
| 2003 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2015 | 0 | 2 | 2 |
| 2018 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
Below are the most recent publications written about "Glucose-6-Phosphate Isomerase" by people in Profiles.
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Glucose 6 Phosphate Isomerase Deficiency, a Rare Hemolytic Anemia Misdiagnosed as Hereditary Spherocytosis. J Pediatr Hematol Oncol. 2023 01 01; 45(1):41-43.
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Cerebrospinal fluid levels of the neurotrophic factor neuroleukin are increased in early Alzheimer's disease, but not in cerebral amyloid angiopathy. Alzheimers Res Ther. 2021 09 24; 13(1):160.
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Integration of proteomics with CT-based qualitative and radiomic features in high-grade serous ovarian cancer patients: an exploratory analysis. Eur Radiol. 2020 Aug; 30(8):4306-4316.
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Comparative study on serum-induced arthritis in the temporomandibular and limb joint of mice. Int J Rheum Dis. 2019 Apr; 22(4):636-645.
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The secreted glycolytic enzyme GPI/AMF stimulates glioblastoma cell migration and invasion in an autocrine fashion but can have anti-proliferative effects. Neuro Oncol. 2018 11 12; 20(12):1594-1605.
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The genetic basis for the adaptation of E. coli to sugar synthesis from CO2. Nat Commun. 2017 11 22; 8(1):1705.
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Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis. Cell Rep. 2015 Dec 22; 13(11):2395-2402.
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Wnt/ß-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance. Nat Commun. 2015 Nov 25; 6:8904.
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Evaluation of synovial mast cell functions in autoimmune arthritis. Methods Mol Biol. 2015; 1220:423-42.
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Insufficient autoantigen presentation and failure of tolerance in a mouse model of rheumatoid arthritis. Arthritis Rheum. 2013 Nov; 65(11):2847-56.