"Chagas Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.
Concept/Terms
Chagas Disease- Chagas Disease
- Disease, Chagas
- American Trypanosomiasis
- Trypanosomiasis, American
- Trypanosomiasis, South American
- South American Trypanosomiasis
- Chagas' Disease
- Disease, Chagas'
Below are MeSH descriptors whose meaning is more general than "Chagas Disease".
Below are MeSH descriptors whose meaning is more specific than "Chagas Disease".
This graph shows the total number of publications written about "Chagas Disease" by people in Harvard Catalyst Profiles by year, and whether "Chagas Disease" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 2 | 0 | 2 |
| 1998 | 1 | 0 | 1 |
| 2000 | 1 | 1 | 2 |
| 2002 | 1 | 0 | 1 |
| 2004 | 2 | 0 | 2 |
| 2006 | 2 | 0 | 2 |
| 2007 | 4 | 0 | 4 |
| 2008 | 2 | 0 | 2 |
| 2009 | 6 | 1 | 7 |
| 2010 | 3 | 0 | 3 |
| 2011 | 3 | 4 | 7 |
| 2012 | 7 | 0 | 7 |
| 2013 | 5 | 2 | 7 |
| 2014 | 3 | 1 | 4 |
| 2015 | 6 | 0 | 6 |
| 2016 | 2 | 4 | 6 |
| 2017 | 8 | 2 | 10 |
| 2018 | 5 | 5 | 10 |
| 2019 | 7 | 1 | 8 |
| 2020 | 6 | 2 | 8 |
| 2021 | 6 | 1 | 7 |
| 2022 | 14 | 0 | 14 |
| 2023 | 8 | 0 | 8 |
| 2024 | 1 | 0 | 1 |
Below are the most recent publications written about "Chagas Disease" by people in Profiles.
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Association between altered tryptophan metabolism, plasma aryl hydrocarbon receptor agonists, and inflammatory Chagas disease. Front Immunol. 2023; 14:1267641.
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Identification of a small-molecule inhibitor that selectively blocks DNA-binding by Trypanosoma brucei replication protein A1. Nat Commun. 2023 07 20; 14(1):4390.
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Fatty acid elongases 1-3 have distinct roles in mitochondrial function, growth, and lipid homeostasis in Trypanosoma cruzi. J Biol Chem. 2023 06; 299(6):104715.
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Proximity-Dependent Biotinylation and Identification of Flagellar Proteins in Trypanosoma cruzi. mSphere. 2023 Jun 22; 8(3):e0008823.
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Vector mapping and bloodmeal metabarcoding demonstrate risk of urban Chagas disease transmission in Caracas, Venezuela. PLoS Negl Trop Dis. 2023 03; 17(3):e0010613.
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Ligand-based virtual screening, molecular dynamics, and biological evaluation of repurposed drugs as inhibitors of Trypanosoma cruzi proteasome. J Biomol Struct Dyn. 2023; 41(23):13844-13856.
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The Intracellular Amastigote of Trypanosoma cruzi Maintains an Actively Beating Flagellum. mBio. 2023 04 25; 14(2):e0355622.
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Cardiomyocyte infection by Trypanosoma cruzi promotes innate immune response and glycolysis activation. Front Cell Infect Microbiol. 2023; 13:1098457.
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mTOR signaling inhibition decreases lysosome migration and impairs the success of Trypanosoma cruzi infection and replication in cardiomyocytes. Acta Trop. 2023 Apr; 240:106845.
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Development of vaccines for Chagas disease (CRUZIVAX): stakeholders' preferences and potential impacts on healthcare. Gac Sanit. 2023; 37:102275.