Phosphogluconate Dehydrogenase

"Phosphogluconate Dehydrogenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An enzyme of the oxidoreductase class that catalyzes the reaction 6-phospho-D-gluconate and NADP+ to yield D-ribulose 5-phosphate, carbon dioxide, and NADPH. The reaction is a step in the pentose phosphate pathway of glucose metabolism. (From Dorland, 27th ed) EC 1.1.1.43.

Descriptor ID

D010734

MeSH Number(s)

D08.811.682.047.150.600

Concept/Terms

Phosphogluconate Dehydrogenase

Below are MeSH descriptors whose meaning is more general than "Phosphogluconate Dehydrogenase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Oxidoreductases [D08.811.682]
Alcohol Oxidoreductases [D08.811.682.047]
Carbohydrate Dehydrogenases [D08.811.682.047.150]
Phosphogluconate Dehydrogenase [D08.811.682.047.150.600]

Below are MeSH descriptors whose meaning is related to "Phosphogluconate Dehydrogenase".

Below are MeSH descriptors whose meaning is more specific than "Phosphogluconate Dehydrogenase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Phosphogluconate Dehydrogenase" by people in Harvard Catalyst Profiles by year, and whether "Phosphogluconate Dehydrogenase" was a major or minor topic of these publication.

Bar chart showing 6 publications over 5 distinct years, with a maximum of 2 publications in 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2007	0	1	1
2013	1	0	1
2019	2	0	2
2021	1	0	1

Below are the most recent publications written about "Phosphogluconate Dehydrogenase" by people in Profiles.

Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function. Cell Rep. 2021 03 09; 34(10):108831.

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6-Phosphogluconate Dehydrogenase Links Cytosolic Carbohydrate Metabolism to Protein Secretion via Modulation of Glutathione Levels. Cell Chem Biol. 2019 09 19; 26(9):1306-1314.e5.

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Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation. Cell Rep. 2019 01 08; 26(2):469-482.e5.

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Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin. Oncogene. 2017 01 12; 36(2):254-262.

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6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov; 17(11):1484-96.

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Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth. Mol Cell. 2014 Aug 21; 55(4):552-65.

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One-step purification of soluble recombinant human 6-phosphogluconate dehydrogenase from Escherichia coli. Protein Expr Purif. 2013 Nov; 92(1):62-6.

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6-Phosphogluconate dehydrogenase regulates tumor cell migration in vitro by regulating receptor tyrosine kinase c-Met. Biochem Biophys Res Commun. 2013 Sep 20; 439(2):247-51.

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Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence. FEBS Lett. 2012 Jul 30; 586(16):2389-95.

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Leishmania donovani and cutaneous leishmaniasis, Sri Lanka. Emerg Infect Dis. 2007 Mar; 13(3):476-8.

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