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Negative Staining

"Negative Staining" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information
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The technique of washing tissue specimens with a concentrated solution of a heavy metal salt and letting it dry. The specimen will be covered with a very thin layer of the metal salt, being excluded in areas where an adsorbed macromolecule is present. The macromolecules allow electrons from the beam of an electron microscope to pass much more readily than the heavy metal; thus, a reversed or negative image of the molecule is created.


publications
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This graph shows the total number of publications written about "Negative Staining" by people in Harvard Catalyst Profiles by year, and whether "Negative Staining" was a major or minor topic of these publication.
Bar chart showing 2 publications over 2 distinct years, with a maximum of 1 publications in 1996 and 2000
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.